Anti-Infectives Flashcards
Antivirals for tx naive HIV pt combines two ___ with either ___ transfer inhibitor or ___ inhibitor or ___
goal is to dec ___, restore ___, prevent development of __ and stop __ of virus
Tx begins at ___ CD4 count
reverse transcriptase, integrase strand, non nucleoside transfer inhibitor, protease inhibitor
viral load, IS fxn, resistance, spread
any level of
HIV enters cell through ___
viral RNA is then __ to cDNA
copied to __ and integrated into ___
viral RNA trxn by __ for packaging/translation into __
__ cleave one of viral products for __/__
cell surface receptors
reverse transcribed
ds DNA, genome
host, proteins
viral proteases, packaging/release
__ incorporated into viral DNA and __ growing polynucleotide
can use __/__ RTIs
also __/__ RTIs
Reverse transcriptase inhibs, terminate
nucleoside/nucleotide
nonnucleoside/nucleotide
__ taken orally
nucleoside RTI becomes __ to active form
abacavir
phosphorylated
Protease inhibitors not commonly used bc of ___
current ones include ___
target viral __ that cleaves pol __ and __ and gag protein
uncleaved protein is ___
virions produced but are __
most PIs are ___ that bind to __ and block activity
cause problems w __ and inhibit __
resistance
darunavir
protease, RT + nuclease
inactive
non-infective
peptidomimetics, proteases
lipid metabolism, p450
integrase inhibitors prevent integration of ___ into genome
dsDNA copy
Acyclovir acts against ___ type of DNA viruses
HSV 1/2 > ___ > __/__
__ is more active against CMV
herpes family
VZV, EBV/CMV
ganciclovir
Acyclovir preferentially ihibits ___ compared to cellular DNA poly
___ binds to DNA during rep
drug is phosphorylated by ___
can be given to __/___ to prevent infection
viral DNA polymerase
inactive enzyme complex
viral thymidine kinase
pregnant women/young kids
Hep B prodces ____ which is reverse transcribed to ___ then partially __ by HBV poly
HBV is __ that uses __ and __
pre genomic RNA,, ssDNA, dsDNA
DNA virus, RNA intermediate/reverse transcriptase
mutations in __ render virus resistant to lamivudine
Interferon analog __ can treat Hep B
active against __ HBV
efficacy measured by levels of ___
tx less than __ assc w recurrence
HBV polymerase
tenofovir
lamivudine resistant
ALT
12 months
Influenza a
for virus to be released, must be disaggregated by _ which are __ hydrolases
if not, __ grabs extracellular receptors
Neuraminidases encoded by virus blocked by __ and __
neuraminidases, glycoside
hemagluttinin
oseltamivir, zanamivir
Hep C spread by __ and __
tx w ___ and ___
Sofosbuvir inhibts HCV __ which is the __ of virus
does not inhibit host __/___ polymerases
main SE of sofosbuvir
IV drugs/needle sticks
sofosbuvir and ledipasvir
NS5B, RNA dep RNA poly
DNA/RNA poly
fatigue/HA
ledipasvir inhibits HCV __ phosphoprotein, required for ___
certain __ respond better
NS5A, viral replication
HCV genotypes
Paritaprevir can treat ___
inhibits viral protease called ___ arresting infection
SE include __ and __ and __
HCV
NS3-4A
sleep loss, rash, itching
C albicans commonly treated with __ or __
azoles/polyenes
