Heme review

Question 1

Neuro findings, high MCV possibilities

___ def
__ due to anti- __ ab
T___
V___

Answer 1

B12 def
Pernicious anemia, IF
terminal ileitis
vegan

Question 2

neuro findings, normal B12, high homocysteine and MMA

cause

__ def w/out neuro sx

Answer 2

B12 def

folate

Question 3

Post sulfa drug hemolytic anemia

cause

another common association

Answer 3

G6PD deficiency

fava beans

Question 4

Mild anemia high MCHC, splenomegaly, positive family history

cause

Answer 4

hereditary spherocytosis

Question 5

sickle cell pt, profoundly anemic

___ due to ___

___ prior to ___

__ after ___ infection

Answer 5

hyperhemolytic crisis, vaso-occlusion

splenic sequestration, splenic autoinfarct

aplastic, parvo B19

Question 6

sickle cell comps
___ with pain mimicking ___

___ osteomyelitits

___ of the ___

Answer 6

acute chest syndrome, PNA

salmonella

avascular necrosis, femoral head

Question 7

Post splenectomy, give vaccines for ___

such as (3)

Answer 7

encapsulated organisms

Pneumococcal, Hib, meningitidis

Question 8

Pentad: Fever, mental status changes, schistocytes, renal dysfunction, low platelets

dz
deficiency of ___, normally a protease that cleaves ___

Answer 8

TTP

ADAMST13, vWF

Question 9

Older individual, massive LAD, splenomegaly, WBC high, lymphocytes

disease

Answer 9

CLL

Question 10

High WBC, all cell lines, mild illness, 9;22 translocation

disease
chromosome
treat w

Answer 10

CML
BCR-ABL
imatinib

Question 11

translocation 15;17
disease

treat w

Answer 11

Acute promyelocytic leukemia

all trans retinoic acid

Question 12

High Ca/protein
Renal failure/high albumin
Anemia
narrow AGAP
bone pain

dz
upregulated ___
malignant __ disorder

Answer 12

multiple myeloma
Osteoclast activating factor, such as IL6
plasma cell

Question 13

Post URI, normal WBC/HCT, very low platelets

dz
bone marrow biopsy shows

Answer 13

ITP

megakaryocytes

Question 14

child, bloody diarrhea, acute kidney injury, thrombocytopenia/anemia

dz
due to

Answer 14

HUS

ETEC

Question 15

Cisplatin/carboplatin side effect

Answer 15

nephrotoxic/acoustic nerve damage

Question 16

Bleomycin/bisulfan SE

Answer 16

PF

Question 17

Vincristine SE

Answer 17

Peripheral neuropathy

Question 18

Doxorubin SE

Answer 18

cardiotoxic

Question 19

Cyclophosphamide SE

Answer 19

hemorrhagic cystitis

Question 20

trastuzumab

monoclonal ab against __, which is a __

leads to ___

Answer 20

HER2, tyrosine kinase

CHF

Question 21

Rituximab

ab against ___, used on ___ such as ___

Answer 21

CD20, B cell neoplasms, NHL

Question 22

Bevacuzimab
monoclonal ab against __
inhibits ___

Answer 22

VEGF

angiogenesis

Question 23

Omalizumab

anti ___, used for ___

Answer 23

IgE, severe asthma

Question 24

Infliximab

anti___, used against __ and __

Answer 24

TNFA, Chrons/RA

Question 25

Abciximab

anti ____
used for some ___

Answer 25

glycoprotein 2b/3A

acute coronary syndromes

Question 26

Urticaria, pruritis, wheezing, fever after transfusion

__
__ hypersensitivity against __ in transfused blood

Answer 26

allergic rxn

Type 1, plasma proteins

Question 27

SOB, bronchospasm, hypoTN, respiratory arrest after transfusion

__ rxn
__ pt from antibodies to __ in blood

Answer 27

anaphylactic

IgA def, IgA

Question 28

Fever, chills w/in 12hrs of blood, no hemolysis

__, ___ rxn
type __
host __ to donor __ and __

blood banks remove __ now

Answer 28

febrile, nonhemolytic transfusion
11
antibodies, antigens, WBC

WBC

Question 29

Fever, hypoTN, flank pain, brown urine, immediate after transfusion

__ rxn
such as ___

Answer 29

acute, hemolytic transfusion

ABO incompatability

Question 30

jaundice, slow hemolysis 1-2 w post transfusion

___ transfusion rxn
anti__/__
hemolysis is __, occurs w __

Answer 30

delayed hemolytic
Kell/Duffy
extravascular, previous exposure

Question 31

SOB/crackles w transfusion

__

Answer 31

volume overload

Question 32

Fever, SOB, noncardiogenic PE on CXR after FFP

TRALI

Answer 32

transfusion associated acute lung injury

Question 33

anemia of chronic disease due to ___
result of __ inability to release __

look for __

Answer 33

chronic inflam
macrophages, Fe

any chronic disease

Question 34

Hemolytic anemia shown w high ___ and ___

IgM cold agglutins seen with __, __, and ___

look for ___ in periphery

Answer 34

bilirubin/lactate

mono, mycoplasma, lymphoma

acrocyanosis

Question 35

Iron deficiency anemia in young women most likely bc of __

test w ___

iron deficiency anemia in postmenopausal women most likely due to ___
test w

Answer 35

menses
endometrial biopsy

occult GI loss
colonoscopy

Question 36

low MCV, normal ferritin and Fe/TIBC ratio, hypochromic red cells possible disease __

look for __ on smear

Answer 36

thalassemia

target cells

Question 37

High cell counts, such as __ and __ cause __ after shower

cyanosis w ___

__ assc w __ mutation

Answer 37

PV, lymphoma, histamine release

deoxygenated hemoglobin

PV, JAK2

Question 38

Platelet count dec w/in days of heparin think ___

steroids cause rise of __ due to ___

consequence is ___

platelet count must be around __ for spontaneous bleed

antibody against ___

Answer 38

HIT

WBC, PMN demargination

thrombosis

5000

PF4

Question 39

Thrombosis, hemolytic anemia, with dark urine in morning dz

__ in urine
__ in morning favors hemolysis

due to loss of __ on cell surface

Answer 39

PNH

hemolyzed red cells
RTA

GPI linked protein

Question 40

__ seen w __ from infection

Answer 40

aplastic anemia, bone marrow suppression

Question 41

__ from defect in akyrin/spectrin seen in ___

Answer 41

red cell membrane instability, Hereditary spherocytosis

Question 42

PT, PTT normal
heavy bleeding w dental work/pregnancy, mucosal bleeding think ____

vWF carries ____
severe dec in F8 can cause __

most have ___, so PTT normal

Answer 42

vWF disease

F8
inc PTT

mild def,