Heme review Flashcards
Neuro findings, high MCV possibilities
___ def
__ due to anti- __ ab
T___
V___
B12 def
Pernicious anemia, IF
terminal ileitis
vegan
neuro findings, normal B12, high homocysteine and MMA
cause
__ def w/out neuro sx
B12 def
folate
Post sulfa drug hemolytic anemia
cause
another common association
G6PD deficiency
fava beans
Mild anemia high MCHC, splenomegaly, positive family history
cause
hereditary spherocytosis
sickle cell pt, profoundly anemic
___ due to ___
___ prior to ___
__ after ___ infection
hyperhemolytic crisis, vaso-occlusion
splenic sequestration, splenic autoinfarct
aplastic, parvo B19
sickle cell comps
___ with pain mimicking ___
___ osteomyelitits
___ of the ___
acute chest syndrome, PNA
salmonella
avascular necrosis, femoral head
Post splenectomy, give vaccines for ___
such as (3)
encapsulated organisms
Pneumococcal, Hib, meningitidis
Pentad: Fever, mental status changes, schistocytes, renal dysfunction, low platelets
dz
deficiency of ___, normally a protease that cleaves ___
TTP
ADAMST13, vWF
Older individual, massive LAD, splenomegaly, WBC high, lymphocytes
disease
CLL
High WBC, all cell lines, mild illness, 9;22 translocation
disease
chromosome
treat w
CML
BCR-ABL
imatinib
translocation 15;17
disease
treat w
Acute promyelocytic leukemia
all trans retinoic acid
High Ca/protein Renal failure/high albumin Anemia narrow AGAP bone pain
dz
upregulated ___
malignant __ disorder
multiple myeloma
Osteoclast activating factor, such as IL6
plasma cell
Post URI, normal WBC/HCT, very low platelets
dz
bone marrow biopsy shows
ITP
megakaryocytes
child, bloody diarrhea, acute kidney injury, thrombocytopenia/anemia
dz
due to
HUS
ETEC
Cisplatin/carboplatin side effect
nephrotoxic/acoustic nerve damage
Bleomycin/bisulfan SE
PF
Vincristine SE
Peripheral neuropathy
Doxorubin SE
cardiotoxic
Cyclophosphamide SE
hemorrhagic cystitis
trastuzumab
monoclonal ab against __, which is a __
leads to ___
HER2, tyrosine kinase
CHF
Rituximab
ab against ___, used on ___ such as ___
CD20, B cell neoplasms, NHL
Bevacuzimab
monoclonal ab against __
inhibits ___
VEGF
angiogenesis
Omalizumab
anti ___, used for ___
IgE, severe asthma
Infliximab
anti___, used against __ and __
TNFA, Chrons/RA
Abciximab
anti ____
used for some ___
glycoprotein 2b/3A
acute coronary syndromes
Urticaria, pruritis, wheezing, fever after transfusion
__
__ hypersensitivity against __ in transfused blood
allergic rxn
Type 1, plasma proteins
SOB, bronchospasm, hypoTN, respiratory arrest after transfusion
__ rxn
__ pt from antibodies to __ in blood
anaphylactic
IgA def, IgA
Fever, chills w/in 12hrs of blood, no hemolysis
__, ___ rxn
type __
host __ to donor __ and __
blood banks remove __ now
febrile, nonhemolytic transfusion
11
antibodies, antigens, WBC
WBC
Fever, hypoTN, flank pain, brown urine, immediate after transfusion
__ rxn
such as ___
acute, hemolytic transfusion
ABO incompatability
jaundice, slow hemolysis 1-2 w post transfusion
___ transfusion rxn
anti__/__
hemolysis is __, occurs w __
delayed hemolytic
Kell/Duffy
extravascular, previous exposure
SOB/crackles w transfusion
__
volume overload
Fever, SOB, noncardiogenic PE on CXR after FFP
TRALI
transfusion associated acute lung injury
anemia of chronic disease due to ___
result of __ inability to release __
look for __
chronic inflam
macrophages, Fe
any chronic disease
Hemolytic anemia shown w high ___ and ___
IgM cold agglutins seen with __, __, and ___
look for ___ in periphery
bilirubin/lactate
mono, mycoplasma, lymphoma
acrocyanosis
Iron deficiency anemia in young women most likely bc of __
test w ___
iron deficiency anemia in postmenopausal women most likely due to ___
test w
menses
endometrial biopsy
occult GI loss
colonoscopy
low MCV, normal ferritin and Fe/TIBC ratio, hypochromic red cells possible disease __
look for __ on smear
thalassemia
target cells
High cell counts, such as __ and __ cause __ after shower
cyanosis w ___
__ assc w __ mutation
PV, lymphoma, histamine release
deoxygenated hemoglobin
PV, JAK2
Platelet count dec w/in days of heparin think ___
steroids cause rise of __ due to ___
consequence is ___
platelet count must be around __ for spontaneous bleed
antibody against ___
HIT
WBC, PMN demargination
thrombosis
5000
PF4
Thrombosis, hemolytic anemia, with dark urine in morning dz
__ in urine
__ in morning favors hemolysis
due to loss of __ on cell surface
PNH
hemolyzed red cells
RTA
GPI linked protein
__ seen w __ from infection
aplastic anemia, bone marrow suppression
__ from defect in akyrin/spectrin seen in ___
red cell membrane instability, Hereditary spherocytosis
PT, PTT normal
heavy bleeding w dental work/pregnancy, mucosal bleeding think ____
vWF carries ____
severe dec in F8 can cause __
most have ___, so PTT normal
vWF disease
F8
inc PTT
mild def,
