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Multisystem 1 > Immunology review > Flashcards

Immunology review Flashcards

1
Q

First step to infection, __ activation via ____

A

macrophage, TLR2

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2
Q

Adaptive response, release of __ and ___
activates PRP such as __

releasing __/__ to attract other cells

__ sample surrounding cells
with exposure/activation by TLR, carry material to __

Migrate to __ area of LN, activating ____

A

PAMPs, DAMPs
TLR

cyto/chemokines

Dendritic cells
LN

T cell, naive t cells

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3
Q

Active DC express __ and __ aka

once T cell actvated via __ and ___, it upregulates __
this allows for other cells to be ___

Local ___ programs T cell polarization, determining ___ release

A

CD80/86 aka CD28

MHC class 2 and CD28, CD40L
activated

environment, cytokine

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4
Q

B cells express antigen to __
interacts w __ on T cell
__ released from T cell cause ___

Th1 inflammation releases __
important for ____, such as
upregulates killing by ___

A

APC
CD40L
cytokines, class switching

INFY, intracellular, Tb
macros

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5
Q

CD8 binds to __ cells
release __/__ to kill cells and begin ___

__ important for antibody dpendent killing in similar mechanism

A 
MHC class 1
perforin/granzyme, apoptosis

NK cells

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6
Q

PMN comes to site of activation bc of release by ___

__ in tissues at all times, secondarily recruited to __

A

TLR

macros, damage site

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7
Q

__ often causes OE

gram neg coccobacillus/rod

A

Pseudomonas

Hib

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8
Q

humoral immune response
body produces __ against __ and __

also activates __/___ for encapsulated bugs

A

ab, virus/toxins

complement/opsonization

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9
Q

X linked agammaglobulinemia
recurrent ___, deficiency of __

no ___

recurrent diarrhea via ___

A

sinopulmonary infections, humoral immunity

tonsils

enterovirus

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10
Q

___ produces protein A to bind Fc portion

A

Staph aureus

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11
Q

YA, new onset recurrent infections, also Giardia infections

think ___
dilated __ greater than bronchial artery

peak ages is __ to __

A

CVID
bronchioles

20-40

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12
Q

silver stain used for __ infections

presence of yeast form eliminates __ and ___ bc they are __ only

A

fungal

mucor/aspergillus, mold

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13
Q

HyperIgM due to deficiency of ___
recurrent __ infections

Prevents __ from interacting with B cells for ___

__ and __ and __ low

A

CD40L
pneumocystis

T cells, class switching

IgG, IgA, IgE

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14
Q

Polysaccharide antigens lead to __ process

prodxn of __, as no __ available

A

T cell independent

IgM, class switching

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15
Q

Gram positive cocci, clusters

catalase __

A

Staph aureus

positive

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16
Q

Strep pyo is gram __
catalase __

group __ and __ hemolytic

A

positive cocci
neg

a, B

17
Q

Strep pneumo gram possitive ___
catalase __

_ hemolytic

A

cocci
negative

A

18
Q

Red cells in spleen cleared by __, helps against ___

spleen produces ____ important for T independent response

concern in __ and __pt

A

macros, bacteremia

Marginal zone b cells

splenectomy, SC disease

19
Q

SW USA, fungi, immunosuppression think

A

coccidiodes

20
Q

lack of vaccination, possible ___

gram __

inhibits protein synthesis via __ of ___

A

C diptheria

+ rod

ADP ribosylation, EF2

21
Q

thrush indicates __ problem, leading to ___ problem

A

T cell, humoral

22
Q

NK cells differ from B/T cells bc they do not require

A

VDJ recomb

23
Q

Cell types presnt in granulomatous infection

predominantly expressing

A

monocytes/macrophages

CD3

24
Q

__ helps with class switching

A

IL 17

25
Q

TSS always caused by __

A

staph aureus toxin 1

26
Q

Clostridium perfringens
gram positive __, ___

think ___

A

rod, anaerobic

puncture wounds

27
Q

NADPH produces ___

without it, cannot destroy __ organisms

sepsis due to __

test w ____

mothers will have half __/__

affected individual ahs ___

A

superoxide

catalase

B. cepacia

nitroblue tetrazolium

normal/affected

no prodxn

28
Q

Hereditary angioedema due to deficiency of ___

affects __ mediated angioedema

will not respond to __/__/__

A

C1 esterase

bradykinin

epi/antihistamines/corticosteroids

29
Q

Type 4 hypersensitivity rxn positive for __

A

CD3

30
Q

Graves dz/Myasthenia gravis have __ hypersensitivity rxn

due to __ to receptor

A

type 2

antibodies

31
Q

first mediator to arise in allergic response

followed by

can have 4hr delayed respjonse from __ and __ relase of mediators

A

histamine

phospholipase A2

mast cells/basophils

Multisystem 1 (21 decks)

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