Immunology review Flashcards
First step to infection, __ activation via ____
macrophage, TLR2
Adaptive response, release of __ and ___
activates PRP such as __
releasing __/__ to attract other cells
__ sample surrounding cells
with exposure/activation by TLR, carry material to __
Migrate to __ area of LN, activating ____
PAMPs, DAMPs
TLR
cyto/chemokines
Dendritic cells
LN
T cell, naive t cells
Active DC express __ and __ aka
once T cell actvated via __ and ___, it upregulates __
this allows for other cells to be ___
Local ___ programs T cell polarization, determining ___ release
CD80/86 aka CD28
MHC class 2 and CD28, CD40L activated
environment, cytokine
B cells express antigen to __
interacts w __ on T cell
__ released from T cell cause ___
Th1 inflammation releases __
important for ____, such as
upregulates killing by ___
APC
CD40L
cytokines, class switching
INFY, intracellular, Tb
macros
CD8 binds to __ cells
release __/__ to kill cells and begin ___
__ important for antibody dpendent killing in similar mechanism
MHC class 1 perforin/granzyme, apoptosis
NK cells
PMN comes to site of activation bc of release by ___
__ in tissues at all times, secondarily recruited to __
TLR
macros, damage site
__ often causes OE
gram neg coccobacillus/rod
Pseudomonas
Hib
humoral immune response
body produces __ against __ and __
also activates __/___ for encapsulated bugs
ab, virus/toxins
complement/opsonization
X linked agammaglobulinemia
recurrent ___, deficiency of __
no ___
recurrent diarrhea via ___
sinopulmonary infections, humoral immunity
tonsils
enterovirus
___ produces protein A to bind Fc portion
Staph aureus
YA, new onset recurrent infections, also Giardia infections
think ___
dilated __ greater than bronchial artery
peak ages is __ to __
CVID
bronchioles
20-40
silver stain used for __ infections
presence of yeast form eliminates __ and ___ bc they are __ only
fungal
mucor/aspergillus, mold
HyperIgM due to deficiency of ___
recurrent __ infections
Prevents __ from interacting with B cells for ___
__ and __ and __ low
CD40L
pneumocystis
T cells, class switching
IgG, IgA, IgE
Polysaccharide antigens lead to __ process
prodxn of __, as no __ available
T cell independent
IgM, class switching
Gram positive cocci, clusters
catalase __
Staph aureus
positive
Strep pyo is gram __
catalase __
group __ and __ hemolytic
positive cocci
neg
a, B
Strep pneumo gram possitive ___
catalase __
_ hemolytic
cocci
negative
A
Red cells in spleen cleared by __, helps against ___
spleen produces ____ important for T independent response
concern in __ and __pt
macros, bacteremia
Marginal zone b cells
splenectomy, SC disease
SW USA, fungi, immunosuppression think
coccidiodes
lack of vaccination, possible ___
gram __
inhibits protein synthesis via __ of ___
C diptheria
+ rod
ADP ribosylation, EF2
thrush indicates __ problem, leading to ___ problem
T cell, humoral
NK cells differ from B/T cells bc they do not require
VDJ recomb
Cell types presnt in granulomatous infection
predominantly expressing
monocytes/macrophages
CD3
__ helps with class switching
IL 17
