Statins

Question 1

Statins are from what class?

Answer 1

HMG-CoA reductase inhibitors

Question 2

Net effect - statins

Answer 2

increase catabolic rate of LDLs, liver’s extraction of IDLs, Reduce plasma levels of LDL, modest decrease in plasma triglycerides

Question 3

MoA

Answer 3

statins will competitively inhibit HMG-CoA reductase, which inhibits synthesis of cholesterol. ALso induces an increase in high-affinity LDL receptors

Question 4

Toxicities

Answer 4

elevation of serum aminotransferase, serum creatinine kinase, BLOOD SUGAR, muscle pain

Question 5

The majority of their effects are on the

Answer 5

LIVER