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Drug Mech > Niacin > Flashcards

Niacin Flashcards

1
Q

Niacin net effects

A

increase HDL levels, decrease total plasma LDLs, decrease triglycerides, decrease plasma levels of lipoproteins

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2
Q

Niacin MoA

A

inhibits VLDL secretion from hepatocytes AND induces clearance by the LPL pathway–> decrease in LDL production; decreases catabolic rate of HDLs, inhibits intracellular lipase of adipose tissue (which reduces VLDL)

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3
Q

Side effects

A

skin flushing (due to production of PGs), glucose intolerance, liver toxicity

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Drug Mech (29 decks)

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