Direct Thrombin Inhibitors

Question 1

Dabigatran indication

Answer 1

thromboembolic disorder prevention

Question 2

Dabigatran MoA

Answer 2

bind competitively to the active site of thrombin, it inhibits thrombin-mediated effects

Question 3

Dabigatran vs warfarin

Answer 3

monitoring and close watch is not required, much less variable than warfarin

Question 4

Dabigatran is associated with higher incidence of

Answer 4

bleeding and GI bleeding, but not intracranial bleeding

Question 5

Patients should stop taking dabigatran how many days before surgery?

Answer 5

1-5