Antifungals Flashcards
1
Q
Which class inhibits Cytochrome P450 Enzyme? what does this lead to?
A
azoles; altered fungal cell
2
Q
Which azoles are less selective? What does this mean?
A
imidazoles; specifically ketoconazole is more potent
3
Q
The fungins make up the class
A
echinocandins; cidal broad
4
Q
the fungins work how?
A
inhibit cell wall synthesis by inhibiting beta 1,3 glucan synthase
5
Q
Flucytosine
A
5-FC
6
Q
5-FC mechanism of action
A
converted to fDUMP - then inhibits DNA synthesis and used with amphotericin B
7
Q
Polyene drugs
A
amphotericin B and Nystatin
8
Q
MoA- nystatin and amphotericin B
A
kill fungal cells by binding to ergosterol - form pores
