Anti-platelet agents

Question 1

GP IIb Receptor antagonists include

Answer 1

Abciximab, Eptifibatide, Tirofiban

Question 2

Abciximab - MoA

Answer 2

binds to BOTH activated and non-activated platelets

Question 3

Eptifibatide & Tirofiban - MoA

Answer 3

mediate binding of fibrinogen to the receptor complex. Activated platelets only

Question 4

GP IIb antagonist toxicities

Answer 4

bleeding and thrombocytopenia

Question 5

What is the IIb/IIIa complex?

Answer 5

a platelet membrane receptor for fibrinogen and vibronectin/other clotting factors

Question 6

PAR 1 antagonists include

Answer 6

vorapaxar (zontivity)

Question 7

Par-1 antagonist indications

Answer 7

approved for oral use to reduce risk of thrombotic cardiovascular events in patients with history of MI or artery disease

Question 8

Vorapaxar MoA

Answer 8

blocks PAR-1, the major thrombin receptor on platelets - inhibits aggregation

Question 9

Vorapaxar toxicity

Answer 9

bleeding, anemia, depression, rash

Question 10

Vorapaxar contraindications

Answer 10

history of stroke, intracranial , intracranial hemorrhage shouldn’t be used with CYP3A4 inhibitors OR inducers

Question 11

Dipyridamole indications

Answer 11

used in combo to prevent cerebrovascular ischemia, also used with warfarin for prevention of embolus