Indirect thrombin inhibitors Flashcards
1
Q
UFH/HMWH indication
A
inhibits blood coagulation by inhibiting thrombin
2
Q
H/LMWH MoA
A
binds to antithrombin causing a comformational change, increases anticoagulat properties - when it binds it creates a complex that exposes its active site for interactions with proteases
3
Q
LMWH indication
A
inhibition of factor XA - less effects on thrombin
4
Q
The low dose regimen is used for
A
prophylaxis after major surgery - high is treatment of embolism, thrombosis
5
Q
Antidote
A
Protamine sulfate - form a stable inactive salt with heparin groups
6
Q
Which is safest for renal insufficiency?
A
UFH
7
Q
Which is more likely to cause heparin-induced thrombocytopenia?
A
UFH
8
Q
Which of the three requires monitoring?
A
UFH
