Antiplatelet misc

Question 1

Which drug binds to both inactive and activated platelets on the GPIIa/IIIb complex?

Answer 1

Abciximab

Question 2

What are Eptifibatide and Tirofiban analogs of?

Answer 2

fibrinogen amino acid sequence - mediates complex

Question 3

What are the three drugs in the GPIIIA antagonist class?

Answer 3

Eptifibatide, Abciximab, Tirofiban

Question 4

What is the brand name for Vorapaxar?

Answer 4

Zontivity

Question 5

Zontivity is part of what drug class?

Answer 5

PAR-1

Question 6

Vorapaxar is approved for what use?

Answer 6

reduce risk of cardiovascular events in patients with peripheral arterial disease

Question 7

Persantine is

Answer 7

Dipyridamole

Question 8

What drug is used in combo with ASA to prevent ischemia?

Answer 8

Dipyridamole

Question 9

Which antiplatelet inhibits uptake of adenosine ?

Answer 9

Dipyridamole (persantine)

Question 10

Which drug is used mainly to prevent MI?

Answer 10

ASA

Question 11

ASA works by inhibiting

Answer 11

synthesis of TXA2 by irreversible acetylation of COX-1 AND COX-2

Question 12

What should not be taken with ASA?

Answer 12

nsaids

Question 13

What are the three thienopyridines?

Answer 13

clopidogrel, prasugrel, ticlopidine

Question 14

How does Prasugrel prevent aggregaton?

Answer 14

binding to the P2Y12 ADP receptor

Question 15

Indications - ticlopidine

Answer 15

preention of thrombotic cardiovascular events

Question 16

Tricagrelor inhibits aggregation by

Answer 16

blocking P2Y12ADP receptor - but shorter duration of action compared to thienopyridines

Question 17

What drug interacts with clopidogrel?

Answer 17

PPIs - they inhibit CYP2C19, which activates clopidogrel. Can be used with other thienopyridines

Question 18

If patients on clopidogrel require a PPI, what should be used?

Answer 18

pantoprazole

Question 19

Which antiplatelet is used in patients with acute coronary syndrome?

Answer 19

ticagrelor