Anti-cancer misc questions

Question 1

Which drug is often administered with allopurinol?

Answer 1

6-MP

Question 2

Which natural product inhibits topoisomerase II

Answer 2

etoposide, teniposide

Question 3

Which drug must be bioactivated to ribosyl and deoxyribosyl before exerting its effects?

Answer 3

5-FU (fluorouracil)

Question 4

Topotecan and Irinotecan are part of what drug class?

Answer 4

Camptothecans

Question 5

Which natural product comes from the mayapple root?

Answer 5

epipodophyllotoxins (etoposide and teniposide)

Question 6

Topotecan works by inhibiting what enzyme?

Answer 6

topoisomerase I (camptothecans)

Question 7

Name the class: paclitaxil, docetaxil, cabazitaxel

Answer 7

taxanes

Question 8

Daunorubicin and Doxorubicin class and cycle

Answer 8

anthracyclines (CCNS)

Question 9

Methotrexate cycle and mechanism

Answer 9

CCS, binds to DHFR (folic acid inhibitor)

Question 10

Methotrexate antidotes

Answer 10

leucovorin, levoleucovorin, glucarpidase

Question 11

Which drug must be activated by HGPRT?

Answer 11

6-MP Mercaptopurine

Question 12

Which drug destroys mitotic spindles through high affinity binding?

Answer 12

taxanes (taxels)

Question 13

Which drug works one of its mechanisms by generating free radical species?

Answer 13

anthracyclines (doxyrubicin, daunorubicin)

Question 14

Which drug fragments DNA by creating a tertiary iron complex?

Answer 14

bleomycin, also the only drug that causes pulmonary toxicity

Question 15

Which drug, upon activation, generates an alkylating electrophilic species?

Answer 15

mitomycin C

Question 16

Which drug has an iron-binding end and a DNA-binding end?

Answer 16

bleomycin

Question 17

Tamoxifil and roloxafene are part of what class?

Answer 17

SERMs

Question 18

Fluvestrant is part of what drug class?

Answer 18

SERDs

Question 19

The androgen receptor antagonists include what drugs?

Answer 19

enzalutamide and flutamide

Question 20

Which drug binds reversibly to the GnRH receptor in the anterior pituitary?

Answer 20

Degarelix (GnRH antagonist)

Question 21

Which drugs cause a release of FSH and LH before inhibition of their release?

Answer 21

leuprolide and goserelin (GnRH agonists)

Question 22

Which drug is an irreversible inhibitor of CYP17A1?

Answer 22

Abiraterone (androgen biosynthesis inhibitor)

Question 23

Which drug may cause an increase in ACTH levels?

Answer 23

abiraterone

Question 24

Of the aromatase inhibitors, which drug binds to the heme group of the aromatase enzyme?

Answer 24

anastrazole and letrozole

Question 25

What is the function of aromatase?

Answer 25

conversion of androgens to estrogens

Question 26

Cetuximab is part of what drug class?

Answer 26

Monoclonal antibodies - bind to Epidermal growth factor

Question 27

Which drug prevents protein binding to ATP?

Answer 27

Imatinib - binds to kinase domain and keeps it in its inactive conformation

Question 28

Vorinostat/Romidepsin class

Answer 28

histone deacetylase inhibitors - correct the balances