Spironolactone Flashcards
1
Q
What class of drug is spironolactone?
A
Aldosterone receptor antagonist
Potassium sparing diuretic
2
Q
What are the uses of spironolactone?
A
Oedema
Nephrotic syndrome
Resistant hypertension
Ascites
3
Q
What is the mechanism of action of spironolactone?
A
Aldosterone antagonist
- inhibits aldosterone > down regulation of ENaC > more Na+ remains in lumen
- H2O is drawn into lumen
4
Q
What are the adverse drug reactions of spironolactone?
A
Hyperkalamia
Gynaecomastia
Hypotension
5
Q
What are the important drug drug interactions with spironolactone?
A
Potassium sparing drugs
6
Q
What are contraindications of spironolactone?
A
Hyperkalaemia
Addison’s
7
Q
How does spironolactone cause gynacemastia?
A
Inhibits androgen receptors
Increased oestrogen > breast growth
