Dalteparin Flashcards
1
Q
What class of drug is dalteparin?
A
Low molecular weight heparins
2
Q
Uses of dalteparin
A
- prevention of venous thromboembolism
- DVT + PE
- acute coronary syndromes with dual anti platelet therapy
- pregnancy instead of warfarin
- before warfarin as bridging treatment
3
Q
What is the mechanism of action of dalteparin?
A
Inhibition of factor Xa by enhancing ATII activity
4
Q
Why does dalteparin not affect thrombin IIa?
A
It is too short to bind to both ATPIII + IIa
5
Q
What are the adverse drug reactions of dalteparin?
A
- bruising + bleeding
- skin reactions
- heparin induce thrombocytopenia
- osteoporosis
- hyperkalaemia
6
Q
What are important drug drug interactions of dalteparin?
A
Other antithrombin drugs
ACEi/ARBs
K+ sparing diuretics
