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Drug Of The Day > Dapagliflozin > Flashcards

Dapagliflozin Flashcards

1
Q

What class of drug is dapaglifozin?

A

SGLT-2 inhibitor

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2
Q

What are the uses of dapagliflozin?

A
  • Type 2 diabetes mellitus if metformin is contraindicated or in conjunction with other hypoglycaemics
  • Type 2 diabetes mellitus with metformin if patient has heart failure HFrEF
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3
Q

What is the mechanism of action of dapaglifozin?

A
  • Competitively reversible SGLT-2 inhibitor in PCT
  • decreases glucose absorption from tubular filtrate
  • increased urinary glucose excretion
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4
Q

What are adverse drug reactions with dapaglifozin?

A
  • UTI + genital infections (due to increased glucose in urine)
  • normoglycaemic DKA
  • thirst
  • polyuria
  • pancreatitis
  • modest weight loss
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5
Q

What are important drug drug interactions with dapaglifozin?

A

Antihypertensives
Other hypoglycaemic agents

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Drug Of The Day (26 decks)

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