Spirochetes Flashcards
Diagnosis of Leptospirosis in dogs
Microscopic Agglutination Test
Papillomatous Digital Dermatitis (PPD)
Grosing cause of lameness of cows in the US dairy industry
Decreased milk production
Lower reproductive efficiency
Disease
Etiologic Agent

Rabbit Syphilis - Vent Disease
Treponema paraluis- cuniculi
Most common leptospira serovars that cause equine leptospirosis
Serovars pomona and grippotyphosa
Clinical signs of Leptospirosis in dogs
Mild or no signs
Acute febrile illness
Renal or hepatic injury, uveitis, pulmonary hemorrhage, abortion
PU/PD, dehydration, vomiting, diarrhea, inappetence, lethargy, abdominal pain
Hepatic and renal Failure
Bleeding abnormalities and DIC
Pathogenic Leptospira species are maintained in
Renal tubules of reservoir animals
Disease
Possible etiologic agent

Papillomatous Digital Dermatitis - PDD
Borrelia is trasmitted via
arthropod vector
Virulence of Borrelia is associated with
Antigenic variation in major outer surface lipoproteins (OPS)
Causative agent of Papillomatoius Digital Dermatitis (PPD) - Hairy Heel Warts (HHW)
Treponema pallidum
Pathogenesis of Lyme Disease
- Tick becomes infected when feeding on bacteremic animal
- Tick ingests blood, spirochete up regulates expression of outer surface protein
- Spirochete moves from midgut to hemolymph to salivary gland
- Transmitted to animal when tick feeds
Treponema pallidum infection in humans
Syphilis
Transmission of Bracyspira
Asymptomatic carrier pigs are the most important mode of transmission
Diagnosis of Brachyspira infection
Direct staining - Wrights Giemsa, Victoria Blue
Causative agent of Swine Dysentery
Brachyspira hyodysenteriae
Clinical signs of Brachyspira infection
Bloody diarrhea, dehydration, weight loss
Grey to strawberry colored feces and dehydration
Brachyspira
Gram Negative
Strong beta-hemolytic
Oxygen tolerant
Anaerobic
Loosly coiled, motile spirochete
Diagnosis of Leptospirosis in cattle and ruminants
Urine FA and PCR
Rabbit Syphilis - Vent Disease
Self limiting disease
Perineal and Facial lesions
Increase susceptibility to other infection
Epidermal hyperplasia with erosion and ulcers
Treatment for Tremponema pallidum in cattle
Spray feet with antibiotic solutions while they are in milkin parlor
Most common vector borne bacterial disease in humans
Lyme Disease
Arthropod vector of Lyme Disease
Ixodes scapularis
Ixodes pacificus
Diagnosis of Rabbit Syphilis
Demonstration of spirochetes in typical lesions
Leptospirosis in swine is charcterized by
Reproductive failure as evidence by infertility and sporadic abortion
Treatment of Leptospirosis in cattle and ruminants
Vaccination and Antibiotics
Clinical signs of Canine Lyme Disease
Fever, acute arthritis, athralgia and lameness
Infection usually subclinical
Species of leptospira host adapted in cattle resulting in reproductive failure due to early embryonic death and repeated bleeding
Leptospira borgpetersenni serovar hardjo
Brachyspira hyodysenteriae is chemotactically attracted to
Hog Mucin
Clinical leptospirosis in horses is most commonly associated with
Abortions and systemic illness in foals
Lesions found in large intestines only
Sharp line of demarcation at ileocecal junction
Fibronecrotic pseudomembranous colitis with granular, hyperemic mucosa - Advanced cases

Brachyspira pilosicoli
Pathogenesis of Leptospira infection
- Penetrates epithelial barriers
- Bacteremia
- Enter liver, kidney, spleen, CNS, genital tract
- Antibodies develop
- Shedding
Causative agent of Avian Borrelosis
Borrelia anserina
Causative agent of Relapsing Fever Borreliae
Borrelia recurrentis
Reservoir animals excrete Leptospira through
Urine
Bracyspira pilosicoli
Causes intestinal spirochetosis in animals and humans
Swine Dysentery affects pigs of what age
Actively growing pigs 6-12 weeks old
Location of flagella in Spirochetes
Periplasmic space
Lesions assoicated with Brachyspira infection
Sharp line of demarcation at ileocecal junction, fibronecrotic pseudomembranous colitis with granular, hyperemic mucosa
Treatment for Canine Lyme Disease
Doxycycline
Clinical signs of leptospriosis in foals
Hemolysis and vasculitis with petechial hemorrhage, hemoglobinuria, anemia, icterus, conjunctival suffusion
Leptospira serovars responsible for swine leptospirosis
Serovar pomona and bratislava
Causative agent of Rabbit Syphilus - Vent Disease
Treponema paraluis-cuniculi

Borrelia

Treponema
Treatment for Leptospirosis in dogs
Supportive care and antibiotics
Clinical signs of Leptospirosis in cattle and ruminants
High fever, hemolytic anemia, hemoglobinuria, jaundice, pulmonary congestion, meningitis
Diagnosis of Canine Lyme Disease
SNAP Test
Western blot
Causative agent of Lyme Disease
Borrelia burgdorferi
Leptospira serovar pomona is endemic in was species
California Sea Lion