Rickettsiales Flashcards

1
Q

Neorikettsia invade what type of cells

A

Surivive in macrophages and mononuclear cells

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2
Q

Anaplasma invade what types of cells

A
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3
Q

Rickettsia rickettsii is transmitted through

A

Ixoided and Dermacentor ticks

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4
Q

Rickettsiales are classified based on

A

Sequence comparison of 16s rRNA gene

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5
Q

Transmission of Coxiella burnetti through

A

Arthropod

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6
Q

Vector of Neorickettsia

A

Fluke

_____________________

All stages within fluke life cycle are infectious

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7
Q

Pathological findings of African Heartwater

A

Vasculitis with effusion

Epithelial/Endothelial hemorrhage

Pericardia effusion and encephalitis

Enlarged - splee, liver, lymph nodes

Bone marrow depression

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8
Q

Causative agent of Potomac Horse Fever

A

Neorickettsia risticii

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9
Q

Infectious Canine Cyclic Thrombocytopenia is caused by

A

Anaplasma platys

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10
Q

Cellular and humoral immune mediated response to Ehrlichia canis conribute to

A

Blood cell destruction

Bone marrow depression

Polyarthritis

Uveitis

Immune complex deposition

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11
Q

Treatment of African Heartwater

A

Tetracycline

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12
Q

Pathogenesis of Salmon Poisoning Disease

A
  • Ingestion of contaminated fish
  • Attachment and penetration of duodenal mucosa by trematode
  • Hemorrhagic enteritis with bacterial spread to lymph node, spleen, liver, lungs, brain and thymus
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13
Q

Clinical signs of Bovine Anaplasmosis

A

Subclinica vs peracute

Depression, anorexia, fever, anemia, icterus

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14
Q

Pathological lesions of Aegyptianellosis

A

Hepatosplenomegaly and punctiform hemorrhages of serosal surface

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15
Q

Causative agent of Canine Granulocytic Ehrlichiosis

A

Ehrlichia ewingii

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16
Q

Causative agent of Aegyptianellosis

A

Aegyptianella pullorum

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17
Q

Neorickettsia

A

Coccoid

Intracytoplasmic

Found within vacuoles of monocytes, macrophages and enterocytes

Gram Negative

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18
Q

Anaplasma

A

Coccoid - ellipsoid bacteria

Cause anemia, thrombocytopenia and leukopenia

Stain blue/purple with Wright-Giemsa

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19
Q

Phase 1 antigenic phase of Coxiella burnetti is indicative of what type of infection

A

Chronic Infection

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20
Q

Causative agent of Equine and Canine Granulocytic Anaplasmosis

A

Anaplasma phagocytophilum

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21
Q

Treatment of Ricketssia rickettsii

A

Chloramphenicol, Fluoroquinolones and Tetracyclines

Supportive Therapy

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22
Q

Causative agent of Human Monocytic Ehrlichiosis

A

Ehrlichia chaffeensis

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23
Q

Diagnosis of Anaplasma platys is by

A

Blood Smear - Giemsa

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24
Q

Neorickettsia helminthoeca infects what type of tissues

A

Lymphoreticular tissues

____________________________

Lymph nodes, peyers patches

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25
Ehrlichia ruminatum replicates in what type of cells
Reticuloendothelial
26
Ehrlichia invade what type of cells
Survivve in phagocytic cells
27
Vector of Neorickettsia risticii
Trematode
28
Ehrlichia chaggeensis or Ehrlichia ewingii
29
Diagnosis of Potomac Horse Fever
History
30
Diagnosis of Coxiella burnetti
Tissue Stain - Gimenez, Giemsa, Modified Ziehl Neelson
31
Pathogenesis of Bovine Anaplasmosis
32
Transmission of anaplasma marginale is through
Hard Ticks \_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_ Boophilus, Dermacentro, Ixodes, Rhipicephalus
33
Vector of Ehrlichia ewingii
Ambyloma Americanum - Lone Star Tick
34
Diagnosis of Rickettsia rickettsii
Culture - Yolk Sac or Cell Culture
35
Vector of Ehrlichia Canis
Rhipicephalus sanguineus - Brown Dog Tick
36
Cause
Anaplasma marginale Bovine Anaplasmosis
37
Diagnosis of Bovine Anaplasmosis
38
Diagnosis of Anaplasma phagocytophilum by
Blood Smear - Giemsa or Wrights
39
Target cells of Neorickettsia helminthoeca
Canine mononuclear cells
40
Phase 2 antigenic phase of Coxiella burnetti is indicative of what type of infection
Acute Infection
41
Causative agent of Salmon Poisoning Disease
Neorickettsia helminthoeca
42
Vector of Ehrlichia chaffeensis
Dermacentro variabilis - American Dog Tick
43
Treatment of Bovine Anaplasmosis
Tetracyclines
44
Transmit what organism
Rickettsia rickettsii
45
Bovine Anaplasmosis causative agent
Anaplasma marginale
46
Causative agent of Rocky Mounthain Fever
Rickettsia rickettsii
47
Neorickettsia risticii has an affinity for
blood monocytes, tissue macrophages, and intestinal epithelial cells
48
Clinical signs of Salmon Poisoning Disease
Fever, vomiting, weightloss, hemorrhagic diarrhea and lymphadenopathy
49
Associated with what organism of Ehrlichia
Ehrlichia ruminantium African Heartwater
50
Causative agent of Human Granulocytic Anaplasmosis
Anaplasma phagocytophilum
51
Clinical signs of chronic Ehrlichia canis infection
Dyspnea Enlarged - spleen, lymph nodes, and liver Polyarthritis CNS disturbances Pulmonary infiltration
52
Clinical signs of Rock Mountain Spotted Fever
High fever, anorexia, vomiting, diarrhea, petechiae or ecchymotic MM, edema Thrombocytopenia and leukopenia
53
Stains to use for Neorikettsia
Macchiavello Giemsa
54
Diagnosis of Salmon Poisoning Disease
Fecal - detection of Fluke eggs
55
Rickettsiae
Gram Negative Non Motile - actin hijack inside cells
56
Clinical signs of Potomac Horse Fever
Acute, watery diarrhea Fever Mild colic Laminitis Leukopenia
57
Pathogenesis of Ehrlichia ruminatum
* Inoculation of the bacteria by tick bite * Multiplication in cells lining the sinusoids of lymph nodes * Vascular dissemination and colonization of endothelial cells
58
Anaplasma phagocytophilum is transmitted through
Ixodes sp ticks
59
Clinical signs of Aegyptianellosis
Ruffled feathers, anorexia, diarrhea, anemia, hyperthermia
60
Diagnosis of African Heartwater
Giemsa stained smears
61
Associated with what organism
Ehrlichia ruminantium African Heartwater
62
Clinical signs of peracute African Heartwater
Fever Collapse and death under convulsion
63
Clinical signs of Infectious Canine Cyclic Thrombocytopenia
64
Treatment of Aegyptianellosis
Tetracyclines
65
Clinical signs of acute infection of Ehrlichia canis
Fever, weight loss, pale MM, lymphadenopthy, epistaxis, thrombocytopenia, leukopenia and anemia
66
Antigenic variablity of Anaplasma due to
Major Surface Protein (MSP2)
67
Anaplasma platys is transmitted through
Rhipicephalus and Dermacenter sp ticks
68
Diagnosis of Ehrlichia canis
Buffy Coat Smear - Giemsa
69
Transmit what organism
Ehrlichia ruminantium African heartwater
70
Vector of Ehrlichia ruminatum
Ambylomma
71
Pathological changes seen with Coxiella burnetti
Vasculitis, placentitis, splenomegaly, mild hepatitis
72
Q Fever of Humans is caused by
Coxiella burnetti
73
Causative agent of Canine Monocytic Ehrlichiosis
Ehrlichia canis
74
Coxiella burnetti
Survives in environment Can be disemminated by aerosol route Bio weapon Reportable
75
Causative agent of African Heartwater
Ehrlichia ruminatum
76
Clinical signs of acute african heartwater
Fever Hyperexcitability Muscle tremors Ataxia Defect in C.P Head pressing Coma Seizures
77
Vector or Aegyptianella pullorum
Tick
78
Pathogenesis of Coxiella burnetti
* Inhalation/Ingestion/Arthropod Bite * Gain access to vascular endothelium, renal and respiratory epithelium * Multiply within phagosome * Mostly asymptomatic disease
79
Treatment of Ehrlichia chaffeensis and ewingii
Tetracyclines and Imidocarb Dipropionate
80
Transmission of what organism
Anaplasma marginale
81
Organism
Anaplasma phagocytophilum
82
Ehrlichiae is an obligate intracellular bacteria of what type of cells
White blood cells
83
Pathogenesis of Ehrlichia canis infection
* Inoculation by tick bite * Incubation period - agent proliferates by binary fission within monocytes * Severe acute disease can develop and then progression to chornic disease