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Rickettsiales Flashcards

1
Q

Neorikettsia invade what type of cells

A

Surivive in macrophages and mononuclear cells

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2
Q

Anaplasma invade what types of cells

A
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3
Q

Rickettsia rickettsii is transmitted through

A

Ixoided and Dermacentor ticks

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4
Q

Rickettsiales are classified based on

A

Sequence comparison of 16s rRNA gene

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5
Q

Transmission of Coxiella burnetti through

A

Arthropod

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6
Q

Vector of Neorickettsia

A

Fluke

_____________________

All stages within fluke life cycle are infectious

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7
Q

Pathological findings of African Heartwater

A

Vasculitis with effusion

Epithelial/Endothelial hemorrhage

Pericardia effusion and encephalitis

Enlarged - splee, liver, lymph nodes

Bone marrow depression

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8
Q

Causative agent of Potomac Horse Fever

A

Neorickettsia risticii

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9
Q

Infectious Canine Cyclic Thrombocytopenia is caused by

A

Anaplasma platys

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10
Q

Cellular and humoral immune mediated response to Ehrlichia canis conribute to

A

Blood cell destruction

Bone marrow depression

Polyarthritis

Uveitis

Immune complex deposition

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11
Q

Treatment of African Heartwater

A

Tetracycline

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12
Q

Pathogenesis of Salmon Poisoning Disease

A
  • Ingestion of contaminated fish
  • Attachment and penetration of duodenal mucosa by trematode
  • Hemorrhagic enteritis with bacterial spread to lymph node, spleen, liver, lungs, brain and thymus
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13
Q

Clinical signs of Bovine Anaplasmosis

A

Subclinica vs peracute

Depression, anorexia, fever, anemia, icterus

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14
Q

Pathological lesions of Aegyptianellosis

A

Hepatosplenomegaly and punctiform hemorrhages of serosal surface

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15
Q

Causative agent of Canine Granulocytic Ehrlichiosis

A

Ehrlichia ewingii

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16
Q

Causative agent of Aegyptianellosis

A

Aegyptianella pullorum

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17
Q

Neorickettsia

A

Coccoid

Intracytoplasmic

Found within vacuoles of monocytes, macrophages and enterocytes

Gram Negative

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18
Q

Anaplasma

A

Coccoid - ellipsoid bacteria

Cause anemia, thrombocytopenia and leukopenia

Stain blue/purple with Wright-Giemsa

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19
Q

Phase 1 antigenic phase of Coxiella burnetti is indicative of what type of infection

A

Chronic Infection

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20
Q

Causative agent of Equine and Canine Granulocytic Anaplasmosis

A

Anaplasma phagocytophilum

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21
Q

Treatment of Ricketssia rickettsii

A

Chloramphenicol, Fluoroquinolones and Tetracyclines

Supportive Therapy

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22
Q

Causative agent of Human Monocytic Ehrlichiosis

A

Ehrlichia chaffeensis

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23
Q

Diagnosis of Anaplasma platys is by

A

Blood Smear - Giemsa

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24
Q

Neorickettsia helminthoeca infects what type of tissues

A

Lymphoreticular tissues

____________________________

Lymph nodes, peyers patches

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25
Q

Ehrlichia ruminatum replicates in what type of cells

A

Reticuloendothelial

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26
Q

Ehrlichia invade what type of cells

A

Survivve in phagocytic cells

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27
Q

Vector of Neorickettsia risticii

A

Trematode

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28
Q
A

Ehrlichia chaggeensis or Ehrlichia ewingii

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29
Q

Diagnosis of Potomac Horse Fever

A

History

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30
Q

Diagnosis of Coxiella burnetti

A

Tissue Stain - Gimenez, Giemsa, Modified Ziehl Neelson

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31
Q

Pathogenesis of Bovine Anaplasmosis

A
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32
Q

Transmission of anaplasma marginale is through

A

Hard Ticks

______________________________

Boophilus, Dermacentro, Ixodes, Rhipicephalus

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33
Q

Vector of Ehrlichia ewingii

A

Ambyloma Americanum - Lone Star Tick

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34
Q

Diagnosis of Rickettsia rickettsii

A

Culture - Yolk Sac or Cell Culture

35
Q

Vector of Ehrlichia Canis

A

Rhipicephalus sanguineus - Brown Dog Tick

36
Q

Cause

A

Anaplasma marginale

Bovine Anaplasmosis

37
Q

Diagnosis of Bovine Anaplasmosis

38
Q

Diagnosis of Anaplasma phagocytophilum by

A

Blood Smear - Giemsa or Wrights

39
Q

Target cells of Neorickettsia helminthoeca

A

Canine mononuclear cells

40
Q

Phase 2 antigenic phase of Coxiella burnetti is indicative of what type of infection

A

Acute Infection

41
Q

Causative agent of Salmon Poisoning Disease

A

Neorickettsia helminthoeca

42
Q

Vector of Ehrlichia chaffeensis

A

Dermacentro variabilis - American Dog Tick

43
Q

Treatment of Bovine Anaplasmosis

A

Tetracyclines

44
Q

Transmit what organism

A

Rickettsia rickettsii

45
Q

Bovine Anaplasmosis causative agent

A

Anaplasma marginale

46
Q

Causative agent of Rocky Mounthain Fever

A

Rickettsia rickettsii

47
Q

Neorickettsia risticii has an affinity for

A

blood monocytes, tissue macrophages, and intestinal epithelial cells

48
Q

Clinical signs of Salmon Poisoning Disease

A

Fever, vomiting, weightloss, hemorrhagic diarrhea and lymphadenopathy

49
Q

Associated with what organism of Ehrlichia

A

Ehrlichia ruminantium

African Heartwater

50
Q

Causative agent of Human Granulocytic Anaplasmosis

A

Anaplasma phagocytophilum

51
Q

Clinical signs of chronic Ehrlichia canis infection

A

Dyspnea

Enlarged - spleen, lymph nodes, and liver

Polyarthritis

CNS disturbances

Pulmonary infiltration

52
Q

Clinical signs of Rock Mountain Spotted Fever

A

High fever, anorexia, vomiting, diarrhea, petechiae or ecchymotic MM, edema

Thrombocytopenia and leukopenia

53
Q

Stains to use for Neorikettsia

A

Macchiavello

Giemsa

54
Q

Diagnosis of Salmon Poisoning Disease

A

Fecal - detection of Fluke eggs

55
Q

Rickettsiae

A

Gram Negative

Non Motile - actin hijack inside cells

56
Q

Clinical signs of Potomac Horse Fever

A

Acute, watery diarrhea

Fever

Mild colic

Laminitis

Leukopenia

57
Q

Pathogenesis of Ehrlichia ruminatum

A
  • Inoculation of the bacteria by tick bite
  • Multiplication in cells lining the sinusoids of lymph nodes
  • Vascular dissemination and colonization of endothelial cells
58
Q

Anaplasma phagocytophilum is transmitted through

A

Ixodes sp ticks

59
Q

Clinical signs of Aegyptianellosis

A

Ruffled feathers, anorexia, diarrhea, anemia, hyperthermia

60
Q

Diagnosis of African Heartwater

A

Giemsa stained smears

61
Q

Associated with what organism

A

Ehrlichia ruminantium

African Heartwater

62
Q

Clinical signs of peracute African Heartwater

A

Fever

Collapse and death under convulsion

63
Q

Clinical signs of Infectious Canine Cyclic Thrombocytopenia

64
Q

Treatment of Aegyptianellosis

A

Tetracyclines

65
Q

Clinical signs of acute infection of Ehrlichia canis

A

Fever, weight loss, pale MM, lymphadenopthy, epistaxis, thrombocytopenia, leukopenia and anemia

66
Q

Antigenic variablity of Anaplasma due to

A

Major Surface Protein (MSP2)

67
Q

Anaplasma platys is transmitted through

A

Rhipicephalus and Dermacenter sp ticks

68
Q

Diagnosis of Ehrlichia canis

A

Buffy Coat Smear - Giemsa

69
Q

Transmit what organism

A

Ehrlichia ruminantium

African heartwater

70
Q

Vector of Ehrlichia ruminatum

71
Q

Pathological changes seen with Coxiella burnetti

A

Vasculitis, placentitis, splenomegaly, mild hepatitis

72
Q

Q Fever of Humans is caused by

A

Coxiella burnetti

73
Q

Causative agent of Canine Monocytic Ehrlichiosis

A

Ehrlichia canis

74
Q

Coxiella burnetti

A

Survives in environment

Can be disemminated by aerosol route

Bio weapon

Reportable

75
Q

Causative agent of African Heartwater

A

Ehrlichia ruminatum

76
Q

Clinical signs of acute african heartwater

A

Fever

Hyperexcitability

Muscle tremors

Ataxia

Defect in C.P

Head pressing

Coma

Seizures

77
Q

Vector or Aegyptianella pullorum

78
Q

Pathogenesis of Coxiella burnetti

A
  • Inhalation/Ingestion/Arthropod Bite
  • Gain access to vascular endothelium, renal and respiratory epithelium
  • Multiply within phagosome
  • Mostly asymptomatic disease
79
Q

Treatment of Ehrlichia chaffeensis and ewingii

A

Tetracyclines and Imidocarb Dipropionate

80
Q

Transmission of what organism

A

Anaplasma marginale

81
Q

Organism

A

Anaplasma phagocytophilum

82
Q

Ehrlichiae is an obligate intracellular bacteria of what type of cells

A

White blood cells

83
Q

Pathogenesis of Ehrlichia canis infection

A
  • Inoculation by tick bite
  • Incubation period - agent proliferates by binary fission within monocytes
  • Severe acute disease can develop and then progression to chornic disease

RUSVM Bacteriology (21 decks)

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