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RUSVM Bacteriology > Antimicrobial Drugs > Flashcards

Antimicrobial Drugs Flashcards

1
Q

Members of the tetracycline group

A

Oxytetracycline

Chlortetracycline

Doxycycline

Minocycline

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2
Q

T/F: You can mix Aminoglycoside and B-Lactam in the same syringe

A

False

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3
Q

Anaphylactic reactions (Type I hypersensitivity) can occur when using B-Lacatms because

A

Anaphylactic reactions (Type I hypersensitivity) can occur when using B-Lacatms because Penicillin acts like a hapten

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4
Q

Lincosamides are bacterio (-static/-cidal)

A

Lincosamides are bacterio (-static/-cidal)

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5
Q

Peptide antibiotics

A

Glycopeptides (Vancomycin)

Polymyxins

Bacitracin

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6
Q

Members of lincosamides group

A

Clindamycin

Lincomycin

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7
Q

T/F: Aminoglycosides are time dependent antimicrobials

A

False

____________________

Concentration dependent

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8
Q

B-Lactams are bacterio (-static/-cidal) antimicrobials

A

B-Lactams are bacterio (-static/-cidal) antimicrobials

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9
Q

Mechanism of action of chloramphenicol

A

Inhibit protein synthesis

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10
Q

Members of the fluoroquinolone family

A

Enrofloxacin

Ciprofloxacin

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11
Q

Members of the aminoglycoside family

A

Gentamicin

Tobramycin

Streptomycin

Kanamycin

Neomycin

Spectinomycin

Amikacin

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12
Q

Aminoglycosides are bacterio (-cidal/-static)

A

Aminoglycosides are bacterio (-cidal/-static)

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13
Q

Sulfa drugs cause allergic reactions in

A

Doberman pinschers

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14
Q

Macrolides are bacterio (-static/-cidal)

A

Macrolides are bacterio (-static/-cidal)

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15
Q

Mechanism of action of lincosamides

A

Inhibit protein synthesis

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16
Q

Mechanism of action of Macrolides

A

Inhibit protein synthesis

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17
Q

T/F: Fluoroquinolones are time dependent antimicrobials

A

False; concentration dependent

18
Q

Mechanism of action of B-Lactams

A

Inhibit cell wall synthesis - peptidoglycan synthesis

Stimulate autolysins to degrade peptidoglycan

19
Q

Sulfa drugs are excreted through

A

Bile, feces, urine

20
Q

Ineffective against anaerobes

A

Aminoglycosides

Fluoroquinolones

21
Q

Members of B-Lactam Group

A

Penicillins

Cephalosporins

Sublactams

Carbapenems

Monobactams

22
Q

Rifampin mechanism of action

A

Inhibit RNA polymerase

23
Q

Synergistic combinations of B-Lactams

A

+ B - lactamase inhibitors (Clavulinic Acid)

+ Aminoglycoside - facillitate entry into cell

+ quinolone - pseudomonas infection

24
Q

Toxicity and adverse effects of tetracyclines

A

Irritant

Cardiovascular effects

Tooth discoloration

Alteration of intestinal flora and enterocolitis - horse

IV administration in horse - cardiovascular collapse

Nephrotoxicosis

25
Q

Chloramphenicols are bacterio (-static/-cidal)

A

Chloramphenicols are bacterio (-static/-cidal)

26
Q

Resistance mechanisms of B-Lactams

A

B-Lactamase - cleaves B lactam ring

Extended spectrum B-lacatamase

Alteration of penicillin binding proteins

27
Q

Tetracyclines are bacterio (-cidal/-static)

A

Tetracyclines are bacterio (-cidal/-static)

28
Q

T/F: Tetracyclines are time dependant antimicrobials

A

True

29
Q

Mechanism of action of aminoglycosides

A

Inhibit protein sythensis

30
Q

Members of the sulfa drug group

A

Sulfonamide

Sulfamethoxazole

Sulfadiazine

31
Q

Antagonistic combinations of B-Lacatms

A

Tetracycline

Chlormanphenicol

32
Q

Members of the macrolides group

A

Erythromycin

Azithromycin

Clarithromycin

33
Q

Tetracycline is a (broad/narrow) spectrum antimicrobial

A

Tetracycline is a (broad/narrow) spectrum antimicrobial

34
Q

Mechanism of action of Fluoroquinolones

A

Inhibit DNA gyrase (DNA replication)

35
Q

Chloramphenicol group

A

Thaimphenicol

Florfenicol

36
Q

Resistance mechanisms of tetracyclines

A

Energy dependent efflux

Ribosomal protection

Chemical modification and catalysis by enzymes

37
Q

Excretion of B-Lacatams is through the

A

Excretion of B-Lacatams is through the kidney

38
Q

Rifampin is bacterio (-static/-cidal)

A

Rifampin is bacterio (-static/-cidal)

____________________

against intra and extra-cellular bacteria

39
Q

Mechanism of action of Tetracyclines

A

Inhibit protein synthesis

40
Q

T/F: B-Lactams involve Time Dependant Killing

A

True

41
Q

Do not combine lincosamides with

A

Macrolides

RUSVM Bacteriology (21 decks)

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