Soft Tissue Sarcoma Flashcards
when are peripheral nerve sheath tumors not considered soft tissue sarcoma?
when they occur with a macroscopic nerve root because these are more difficult to treat due to location
can canine soft tissue sarcomas arise from any anatomical site in the body?
yes
if a biopsy is done, where must the track be?
in an area that will be surgically excised
is marginal excision recommended?
no
what is the metastatic rate for intermediate and low-grade soft tissue sarcomas?
<10%
what are the margins like with soft tissue sarcoma surgery?
3 cm
what are tumor cells at the margin of excised tissue associated with?
consistently with decreased rates of survival
what is low grade tumor recurrence with incomplete resection?
35%
what can pre-operative radiation help with?
“sterilize” perimeter and potentially allow for a smaller surgery
what is the metastatic rate of feline injection site sarcomas?
30%
what does canine soft tissue sarcoma arise from?
fibroblasts
what neoplasias are included in soft tissue sarcoma?
fibrosarcoma
myxosarcoma
perivascular wall tumor- hemangiopericytoma
peripheral nerve sheath tumor
how do soft tissue sarcomas metastasize?
hematogenous route
can cytology grade sarcomas?
no
biopsy may be able to
what is excisional biopsy/marginal excision?
neoplasia is removed with no margin of grossly normal tissue
what is canine soft tissue sarcoma surrounded by?
pseudocapsule
tumor cells can extend far beyond capsule
what is a margin?
amount of skin and tissue removed around the circumference of the tumor
what determines differentiation score?
1: well differentiated, resemble normal mesenchymal tissue
2: poorly differentiated
3: undifferentiated, cannot identify tissue of origin
what is median survival following complete excision of a low or intermediate grade soft tissue sarcoma?
> 1500 days
what are injection site sarcomas found to contain?
gray-brown foreign substance: aluminum
when should you suspect feline injection site sarcoma?
persists >3months
large than 2cm
increasing in size one month post injection
what is feline post traumatic ocular sarcoma?
syndrome where a sarcoma develops in the eye post trauma or chronic uveitis
what is rate of recurrence with feline injection site sarcomas directly related to?
success of first surgery
