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A. Small Animal Medicine and Surgery II > Histiocytic Diseases > Flashcards

Histiocytic Diseases Flashcards

1
Q

what type of disease is cutaneous histiocytosis?

A

immune mediated disease
disease of activated interstitial dermal dendritic cells

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2
Q

who is systemic histiocytosis seen in primarily?

A

familial disease of bernese mountain dogs

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3
Q

what type of cells are in cutaneous histiocytoma?

A

langerhans cells

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4
Q

what is metastatic histiocytoma classified as?

A

cutaneous langerhans cell histiocytosis

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5
Q

what does histopathology and cytology of histiocytic sarcoma show?

A

characteristic multi-nucleate giant cells

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6
Q

what is the origin of feline histiocytic sarcoma?

A

macrophage

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7
Q

what is a histiocyte?

A

CD34+ committed stem cell precursors
macrophages
dendritic cells

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8
Q

what do macrophages do?

A

process and present antigens in association with MHC-II molecules

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9
Q

what do dendritic cells do?

A

process and present antigens
work with T cells to initiate and immune response

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10
Q

what are langerhans cells?

A

epidermal dendritic cells
express E-cadherin

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11
Q

what do langrhans cells do?

A

reside in epidermis
recognize, process, present antigens to T lymphocytes

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12
Q

what are interstitial dendritic cells associated with?

A

lymphoid tissue

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13
Q

what do cutaneous histiocytosis look like?

A

multiple non-painful, non-pruritic plaques and nodules

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14
Q

what is systemic histiocytosis like?

A

like cutaneous histiocytosis but involves mucous membranes, lymphoid organs, and bone marrow
ocular lesions very common

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15
Q

what is survival of systemic histiocytosis?

A

2-48 months

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16
Q

what is cutaneous and systemic histiocytosis?

A

disease of disordered immune regulation arising from defective interaction of dendritic cells and T cells
chronic proliferation of dendritic cells and T cells

17
Q

who is cutaneous histiocytoma seen in?

A

young dogs
head and feet

18
Q

what correlates with spontaneous regression of cutaneous histiocytoma?

A

infiltration of CD8+ cytotoxic T cells

19
Q

what is metastatic histiocytoma?

A

widespread epidermal dendritic cell neoplasia

20
Q

who usually gets solitary histiocytic sarcoma?

A

flat-coated retrievers
also golden and labrador retrievers

21
Q

what is solitary histiocytic sarcoma frequently associated with?

A

joint instability

22
Q

what is the cell lineage of histiocytic sarcoma?

A

dendritic cells

23
Q

what are potential locations of solitary histiocytic sarcoma?

A

periarticular
pulmonary
spleen

24
Q

what is disseminated histiocytic sarcoma like?

A

multiple tumors
aggressive multi-centric disease

25
Q

which dogs usually get disseminated histiocytic sarcoma?

A

bernese mountain dogs 25%
rottweilers

26
Q

what is CCNU/lomustine chemotherapy?

A

myelosuppressive
oral chemotherapy

27
Q

what is hemophagocytic histiocytic sarcoma?

A

diffuse histiocytic infiltration of spleen

28
Q

what is feline progressive histiocytosis like?

A

multiple non-pruritic skin lesions
cutaneous form of histiocytic neoplasia
interstitial dendritic cells
slowly progressive

29
Q

where can feline histiocytic sarcoma be?

A

spleen
bone marrow
liver

A. Small Animal Medicine and Surgery II (27 decks)

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