Slideshow 4 Part 2 Flashcards
Pedigree def
a graph of relationships among individuals upon which we superimpose the hadence of a phenotype of interest
Affected individual
individuals who bear the phenotype of interest
unaffected individual
individual who does not bear the phenotype of interest
What can the pedigree tell us
the type of inheritance
Sex linkage options
X linked dominant
X linked recessive
Y linked
Austosomal phenotypes
autosomal dominant
autosomal recessive
X linked dominant phenotypes clues
affected males always produce affected daughters
affected males never produce affected sons
affected males always produce affected daughters.
what is it
X linked dominant phenotypes
affected males never produce affected sons
what is it
X linked dominant phenotypes
X linked recessive phenotypes clues
phenotype observed in males much more frequently than females
no offspring of an affected male shows the phenotype
daughters of an affected male are all carriers, phenotype re-emerges in half of her sons
phenotype observed in males much more frequently than females
what is it
x linked recessive
no offspring of an affected male shows the phenotype
what is it
x linked recessive
daughters of an affected male are all carriers, phenotype re-emerges in half of her sons
what is it
x linked recessive
Y linked clues
only affected males
daughters of affected males do not pass on the phenotype to their sons
only affected males
what is it
y linked
daughters of affected males do not pass on the phenotype to their sons
what is it
y linked
Autosomal dominant
phenotypes seen every generation
affected mothers of fathers transmit the phenotype to sons and daughters
this is NOT sex linked
phenotypes seen every generation
what is it
autosomal dominant
affected mothers of fathers transmit the phenotype to sons and daughters
what is it
autosomal dominant
not sex linked
autosomal
sons and daughters equally likey to be affected clues
affected offspring are produced from two unaffected parents
rare in the pedigree
sons and daughters equally likey to be affected
affected offspring are produced from two unaffected parents
what is it
autosomal recessive
rare in the pedigree
what is it
autosomal recessive
sons and daughters equally likey to be affected
what is it
autosomal recessive