Slideshow 4 Flashcards
what is cancer at its core
unregulated or unchecked cell division
What does haplosufficient and haploinsufficient describe
used to describe genes with respect to a specific trait
what are the two ways genes predispose an individual to cancer
Oncogens and tumor suppresor genes
Oncogens are haplosufficient or haploinsufficient
haploinsufficient
TUmor suppresor genes are haplosufficient or haploinsufficient
haplo sufficient
where is the barrier
between G1 and S
what happens in oncogens
one wild type is not enough to fight it off
what happens in tumor suppresor genes
one wild type is enough to fight it off
what geneotype leads to cancer in oncogens and tumor suppresor genes
in oncogens: A:a or a:a
in tumor sg: only a:a
Retinoblastoma 1 is a what , and what does that mean
tumor suppresor gene, both alleles must be mutant to initiate tumor growth
WHy is one mutant allele not enough to bring about retinoblastoma
one dose of RB protein is enough to inhibit EZF action
Hereditary def
started with a strike against you (+,-) and turned to (-,-)
non-hereditary def
started with no strikes, both mutated (+,+), turned to (-,-)
sex chromosomes found how in male?
In at least 2 distinct forms
Pseudoautosomal region allow for what
regions of both sez chromosomes allow the distinct sex chromosomes to find each other in the heterogametic sex and synapse in prophase 1