Sleep/ARAS Flashcards
Ascending reticular activating system
promotes wakefulness with monoamines and acetylcholine
Lateral hypothalamus
orexin promotes wakefulness
melanin-concentrating hormone promotes sleepiness
This disease is a complete loss of orexin secretion
narcolepsy
Beta waves
awake and thinking (low amplitude)
Alpha waves
eyes closed and relaxed
Theta waves
drowsy
Delta waves
slow-wave sleep (high amplitude)
In which stage of sleep do sleep spindles occur?
II
Restorative sleep
first 1 hr.
What is the pathology of apnea?
loss of palate muscle tone
=>collapse and wake up
Pontine tegmental nuclei
part of ascending reticular activating system
LDT
PPT
activate thalamus during wakeing
Reticular nucleus of thalamus
inhibits thalamus, promotes sleeping
Reticular nucleus of thalamus and bursts
complex pathway causes brief bursts of cortical activity and immediate inhibition
REM behavior disorder pathology
loss of orexin
ACh from ARAS during
wake and REM (subset)
Monoamines active during
wake and non-REM
Orexin active during
wake
MCH active during
REM
VLPO/MNPO active during
preoptic areas
non-REM and REM
PPT and LDT function to do this during wakefulness and REM
activation thalamus–> activate cortex
Reticular nucleus functions to
inhibit thalamus during non-REM
+ complex feedback system
= BURSTS
