Antidepressants Flashcards by Robbie Gruhl | Brainscape

Q

Amine hypothesis of depression

A

disruption of 5HT and NE w/ downstream effects

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

BDNF (brain-derived neurotropic factor)

A

important for maintaining brain structure

increased w/ long term antidepressant use

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What are the 4 classes of antidepressants?

A

TCA
MAOI
SSRI
dual-mechanism

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What are the two TCAs?

A

desipramine

imipramine

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What is the mechanism of TCAs?

A

block 5-HT and NE reuptake

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What is the danger of TCAs?

A

low therapeutic index ==> suicide

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What is the MAOI?

A

phenelzine

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What is the mechanism of MAOIs?

A

irreversibly bind MAO

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What are the 3 SSRIs?

A

fluoxetine
escitalopram
sertaline

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Which receptor produces SSRI effects?

A

5-HT-2A

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Venlafaxine

A

blocks 5-HT and NE reuptake

but not in adregenic system

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Mirtazapine

A

blocks alpha-2 autoreceptors

NE in adjacent cell

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Buproprion

A

blocks 5-HT and NE reuptake

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Ketamine

A

TRIPPY

How well did you know this?

1

Not at all

2

3

4

5

Perfectly