Cerebrovascular Diseases Flashcards
What causes global cerebral ischemia?
hypotension
Mild global cerebral ischemia Sx
transient confusion
Severe global central ischemia Sx
persistent vegetative state or brain death
Which cell type is most susceptible to hypoxic damage?
neurons
What are watershed areas?
areas between major artery supplies, most susceptible to global cerebral ischemia
Red neurons
dead neurons
usually after infarction
Gray-white demarcation loss
after global cerebral ischemia
What is the difference between ischemic and hemorrhagic infarcts?
hemorrhagic often arise from heart, embolus usually moves and reprofusion occurs –> hemorrhage
What are shower emboli?
cause punctate hemorrhages, usually come from heart
Ischemic infarcts
arise from atherosclerotic plaque
Hemorrhagic infarcts
repurfusion injury after thrombus moves. repurfusion causes previously blocked vessels to rupture
tPA in hemorrhagic infarcts
not given
When can you see red neurons?
about 12 hr.
Lacunar infarcts
caused by hypertension, causes sclerosis to build up (very small)
Slit hemorrhages
hypertension causes rupture of small vessels