Antipsychotics Flashcards
Antipsychotics work primarily at which receptor type?
D2 antagonist
Chloropromazine
D2 antagonist in limbic system
Chloropromazine generation
first generation
Clozapine generation
second generation
Clozapine mechanism
D2 antagonist
+
5-HT-2A antagonist
Why is it good that clozapine is a 5-HT-2A antagonist?
5-HT-2A receptor is found at the terminus of dopiminergic neurons. usually 5-HT is responsible for inhibiting DA release. clozapine blocks this effect and allows dopamine to be secreted, preventing some side effects of D2 receptor antagonism
Mesolimbic pathway in schizophrenia
D2 receptors are overactive creates positive symptoms of schizophrenia
Mesocortical pathway in schizophrenia
responsible for negative Sx
Nigrostriatal pathway in schizophrenia
D2 antagonist creates Parkinsonian illness
Tuberoinfundibular pathway
D2 antagonist allows prolactin to be released
Pathology w/ nigostriatal pathway and D2 antagonist
Parkinsonian illness
Pathology w/ mesocortical pathway in schizophrenia
negative Sx
Pathology w/ mesolimbic pathway and schizophrenia
D2 receptors are overactive creating positive Sx
Tuberoinfudibular pathway pathology w/ D2 antagonist
galactorrhea
amenorrhea
sexual dysfunction
Why is a D2 antagonist + 5-HT-2A antagonist preferable to a simple D2 antagonist?
it antagonizes D2 in mesolimbic pathway + allows dopamine release the mesocortical, nigrostriatal, and tuberoinfundibular pathways
