Neurodegenerative Diseases Flashcards
What do you use congo red stain for?
amyloid
What are the two classic findings of AD?
neurofibrillary tangles
beta-amyloid bodies
What are neurofibrillary tangles composed of?
tau
Which comes first, amyloid beta or tau?
amyloid-beta
Pick disease big 2 Sx
personality and language changes
Pick disease lobe changes
frontal and temporal lobes
At what age is dementia considered “normal” in the elderly?
never, it always has pathology
When are amyloid plaques in AD found?
extracellularily
Where are neurofibrillary tangles found?
intracellularily
Where is amyloid beta normally found?
transmembranous protein
Where is tau protein normally found?
associated with microtubules
Mask fascies and pill rolling tremor are found in which disease?
Parkinson disease
You can say it is Parkinson when…
patient responds to L-dopa
Amylotropic lateral sclerosis etiology
degeneration of motor neurons
Cause of death ALS
respiratory compromise
