Regeneration Science Flashcards
1
Q
What is a glial scar?
A
mammalian CNS lesion that prevents macrophages from coming in and cleaning up
2
Q
Wallerian degradation
A
occurs when Schwann cells detach from axons to help clean up-blocking axoplasmic flow
3
Q
What is the problem with PNS regeneration?
A
improper tracking: nerves may not reinnervate to correct area
4
Q
Glial scars result from these factors affecting regrowth
A
Nogo, MAG, OMgp
Rho –> Rock
5
Q
Chromatolysis
A
Nissl body dissolution
in cell death
6
Q
Distal axonopathy
A
degeneration of axon and myelin (distally first)
7
Q
What clears broken axons and myelin?
A
macrophages
