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MSK Exam 1 Spring 2015 > Skin Pathology IV > Flashcards

Skin Pathology IV Flashcards

1
Q

mastocytosis

A

spectrum of rare disorders - increased numbers of cutaneous mast cells

pruritis, flushing, rhinorrhea, dermal edema, erythema

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2
Q

darier sign

A

wheal formation with rub skin of mastocytosis

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3
Q

urticaria pigmentosa

A

cutaneous form of mastocytosis - mainly in children

favorable prognosis

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4
Q

systemic mastocytosis

A

in adults
-much poorer prognosis

mutations in c-KIT

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5
Q

urticaria

A

hives

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6
Q

mast cell and IgE dependent

A

acute allergic rxn

medical emergency

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7
Q

mast cell dependent and IgE independent

A

usually drug or other substance

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8
Q

mast cell independent and IgE independent

A

aspirin - vasodilation

hereditary angioneurotic edema - C1 inhibitor deficiency

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9
Q

wheal

A

transient edematous erythematous plaque secondary to acute allergic rxn seen in hives

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10
Q

eczema

A

spongiotic dermatitis

epidermial edema

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11
Q

spongiosis

A

intercellular edema**

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12
Q

boiling over papulovesicular lesion that is oozing or crusty

A

spongiotic dermatitis

prominent lymphocytes in dermis and epidermis with epidermal edema

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13
Q

T cell type IV hypersensitivity rxn

A

with spongiotic dermatitis

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14
Q

target with red center

A

erythema multiforme

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15
Q

erythema multiforme

A

CD8 T cell hypersensitivity - to drugs, infection, malignancy, collagen vascular disorder

herpes, histoplasmosis, salmonella, leprosy, antibiotics, salicylates, anti-malarials

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16
Q

stevens johnon syndrome

A

febrile form of erythema multiforme
-in children

erosions and hemorrhagic crusting of lips, oral mucosa, urethra

bacterial superinfection life threatening

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17
Q

toxic epidermal necrolysis

A

variant of erythema multiforme

-mucocutaneous epithelial necrosis and sloughing

analagous to 3rd degree burns

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18
Q

seborrheic dermatitis

A

involves skin with high density of sebaceous glands - scalp, forehead, nasolabial bolds, presternum
-but NOT disease of sebaceous glands

chronic dermatitis - more common than psoriasis

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19
Q

A skin condition that causes scaly patches and red skin, mainly on the scalp

A

seborrheic dermatitis

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20
Q

greasy scaly scalp

A

seborrheic dermatitis

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21
Q

infection with seborrheic dermatitis

A

malassezia furfur

improved by use of topical antifungal

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22
Q

psoriasis

A

associated with arthritis, myopathy
-elbows, knees, scalp, lumbosacral region, glans penis

also see nail changes

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23
Q

koebner phenomenon

A

trauma induces psoriatic lesions

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24
Q

well demarcated, pink salmon colored plaque

25
association with psoriasis
HLA-Cw0602 increased CD4 T cells sensitize cells set off other T cells causing increased cytokines leading to epidermal proliferation
26
bleeding if tear it off
auspitz sign - with psoriasis
27
lichen simplex chronicus
chronic rubbing or scratching if nodular - prurigo nodularis
28
lichen planus
self limited disease - leaves postinflammatory hyperpigmentation
29
chronic inflammatory condition of skin and oral cavity
lichen planus spontaneously resolves after 1-2 years
30
koebner phenomenon
skin lesion on lines of trauma seen with lichen planus
31
sawtoothing
infiltrate of lymphocytes at dermoepidermal junction, hyperkeratosis, hypergranulosis and rete ridges seen in lichen planus
32
civatte bodies
apoptotic squamous cells | -seen in lichen planus
33
discoid lupus erythematous
cutaneous manifestations of SLE with no systemic sx excessive sun exposure triggers skin lesions - butterfly malar rash
34
1/3 of SLE patients
will have cutaneous findings
35
granular deposits of IgG and C3 at dermoepidermal junction
positive band test in lupus erythematous** basal lamina deposition
36
1/3 of all SLE patients
will have cutaneous findings
37
rosascea
30-60yo females pre-rosascea - flushing erythematotelengiectatic papulopustular phymatous perifollicular inflammation
38
rhinphyma
thick nose with rosacea
39
intraepidermal blister beneath stratum granulosum with scant or no inflammation
common friction blister
40
pemphigus
life threatening autoimmune disorder - IgG autoAb to desmosomes - 30-60yo patients tx- immunosuppression multiple variants - determined by level of blister and clinical manifestations
41
subcorneal blister
roof of blister is stratum corneum
42
suprabasal blister
portion of epidermis forms roof
43
subepidermal blister
epidermis splits from dermis
44
pemphigus vulgaris
80% of cases mucosa and scalpe, face, axilla, groin -classic bullous disease
45
pemphigus vegetans
rare verrucous plaques instead of blisters - axilla, groin, flexural surfaces
46
pemphigus foliaceus
benign course -face, scalp, chest, back epidemic in south america
47
pemphigus erythematous
mild localized form of foliaceus which involves malar area of face
48
paraneoplastic pemphigus
with malignancy - lymphoma
49
autoAb against desmoglein 1 and 3
pemphigus vulgaris most common reticualr or fishnet pattern of deposition - loss of cell cell adhesions - suprabasal acantholysis** untreated - fatal deeper suprabasal epidermis blisters
50
Dsg 1 vs. 3
1 - superficial lesion | 3 - low lesion - worse
51
AutoAb against Dsg1
pemphigus foliaceous superficial subcorneal blister
52
autoAbs for BPAG2
bullous pemphigoid -BPAG2 - component of hemidesmosome blisters more resistant to rupture -areas more prone to rubbing - inner thigh, flexor surfaces of arms and axilla blisters at level of lamina lucida and BM
53
IgA autoAbs to fibrils anchoring hemidesmosomes
dermatitis herpetiformis
54
IgA for gliadin attacks reticulin in dermal papillae fibrils
dermatitis herpetiformis
55
dermatitis herpetiformis
rare -males, 30-40yo associated with celiac disease - anti-gliadin Abs** intensely pruritic plaques and vesicles
56
inflammation of subQ adipose tissue
panniculitis septal or lobular**
57
septal fatty inflammation
erythema nodosum with infection
58
lobular fatty inflammation
unknown etiology - possible fasculitis
59
relapsing febrile nodular panniculitis in kids and adults
webere christain disease

MSK Exam 1 Spring 2015 (21 decks)

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