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MSK Exam 1 Spring 2015 > Skin Pathology IV > Flashcards

Skin Pathology IV Flashcards

1
Q

mastocytosis

A

spectrum of rare disorders - increased numbers of cutaneous mast cells

pruritis, flushing, rhinorrhea, dermal edema, erythema

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2
Q

darier sign

A

wheal formation with rub skin of mastocytosis

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3
Q

urticaria pigmentosa

A

cutaneous form of mastocytosis - mainly in children

favorable prognosis

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4
Q

systemic mastocytosis

A

in adults
-much poorer prognosis

mutations in c-KIT

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5
Q

urticaria

A

hives

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6
Q

mast cell and IgE dependent

A

acute allergic rxn

medical emergency

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7
Q

mast cell dependent and IgE independent

A

usually drug or other substance

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8
Q

mast cell independent and IgE independent

A

aspirin - vasodilation

hereditary angioneurotic edema - C1 inhibitor deficiency

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9
Q

wheal

A

transient edematous erythematous plaque secondary to acute allergic rxn seen in hives

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10
Q

eczema

A

spongiotic dermatitis

epidermial edema

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11
Q

spongiosis

A

intercellular edema**

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12
Q

boiling over papulovesicular lesion that is oozing or crusty

A

spongiotic dermatitis

prominent lymphocytes in dermis and epidermis with epidermal edema

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13
Q

T cell type IV hypersensitivity rxn

A

with spongiotic dermatitis

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14
Q

target with red center

A

erythema multiforme

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15
Q

erythema multiforme

A

CD8 T cell hypersensitivity - to drugs, infection, malignancy, collagen vascular disorder

herpes, histoplasmosis, salmonella, leprosy, antibiotics, salicylates, anti-malarials

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16
Q

stevens johnon syndrome

A

febrile form of erythema multiforme
-in children

erosions and hemorrhagic crusting of lips, oral mucosa, urethra

bacterial superinfection life threatening

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17
Q

toxic epidermal necrolysis

A

variant of erythema multiforme

-mucocutaneous epithelial necrosis and sloughing

analagous to 3rd degree burns

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18
Q

seborrheic dermatitis

A

involves skin with high density of sebaceous glands - scalp, forehead, nasolabial bolds, presternum
-but NOT disease of sebaceous glands

chronic dermatitis - more common than psoriasis

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19
Q

A skin condition that causes scaly patches and red skin, mainly on the scalp

A

seborrheic dermatitis

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20
Q

greasy scaly scalp

A

seborrheic dermatitis

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21
Q

infection with seborrheic dermatitis

A

malassezia furfur

improved by use of topical antifungal

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22
Q

psoriasis

A

associated with arthritis, myopathy
-elbows, knees, scalp, lumbosacral region, glans penis

also see nail changes

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23
Q

koebner phenomenon

A

trauma induces psoriatic lesions

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24
Q

well demarcated, pink salmon colored plaque

A

psoriasis

25
Q

association with psoriasis

A

HLA-Cw0602

increased CD4 T cells sensitize cells set off other T cells causing increased cytokines leading to epidermal proliferation

26
Q

bleeding if tear it off

A

auspitz sign - with psoriasis

27
Q

lichen simplex chronicus

A

chronic rubbing or scratching

if nodular - prurigo nodularis

28
Q

lichen planus

A

self limited disease - leaves postinflammatory hyperpigmentation

29
Q

chronic inflammatory condition of skin and oral cavity

A

lichen planus

spontaneously resolves after 1-2 years

30
Q

koebner phenomenon

A

skin lesion on lines of trauma

seen with lichen planus

31
Q

sawtoothing

A

infiltrate of lymphocytes at dermoepidermal junction, hyperkeratosis, hypergranulosis and rete ridges

seen in lichen planus

32
Q

civatte bodies

A

apoptotic squamous cells

-seen in lichen planus

33
Q

discoid lupus erythematous

A

cutaneous manifestations of SLE with no systemic sx

excessive sun exposure triggers skin lesions - butterfly malar rash

34
Q

1/3 of SLE patients

A

will have cutaneous findings

35
Q

granular deposits of IgG and C3 at dermoepidermal junction

A

positive band test in lupus erythematous**

basal lamina deposition

36
Q

1/3 of all SLE patients

A

will have cutaneous findings

37
Q

rosascea

A

30-60yo females

pre-rosascea - flushing

erythematotelengiectatic
papulopustular
phymatous

perifollicular inflammation

38
Q

rhinphyma

A

thick nose with rosacea

39
Q

intraepidermal blister beneath stratum granulosum with scant or no inflammation

A

common friction blister

40
Q

pemphigus

A

life threatening autoimmune disorder

  • IgG autoAb to desmosomes
  • 30-60yo patients

tx- immunosuppression

multiple variants - determined by level of blister and clinical manifestations

41
Q

subcorneal blister

A

roof of blister is stratum corneum

42
Q

suprabasal blister

A

portion of epidermis forms roof

43
Q

subepidermal blister

A

epidermis splits from dermis

44
Q

pemphigus vulgaris

A

80% of cases

mucosa and scalpe, face, axilla, groin
-classic bullous disease

45
Q

pemphigus vegetans

A

rare

verrucous plaques instead of blisters - axilla, groin, flexural surfaces

46
Q

pemphigus foliaceus

A

benign course
-face, scalp, chest, back

epidemic in south america

47
Q

pemphigus erythematous

A

mild localized form of foliaceus which involves malar area of face

48
Q

paraneoplastic pemphigus

A

with malignancy - lymphoma

49
Q

autoAb against desmoglein 1 and 3

A

pemphigus vulgaris
most common

reticualr or fishnet pattern of deposition - loss of cell cell adhesions - suprabasal acantholysis**

untreated - fatal

deeper suprabasal epidermis blisters

50
Q

Dsg 1 vs. 3

A

1 - superficial lesion

3 - low lesion - worse

51
Q

AutoAb against Dsg1

A

pemphigus foliaceous

superficial subcorneal blister

52
Q

autoAbs for BPAG2

A

bullous pemphigoid
-BPAG2 - component of hemidesmosome

blisters more resistant to rupture
-areas more prone to rubbing - inner thigh, flexor surfaces of arms and axilla

blisters at level of lamina lucida and BM

53
Q

IgA autoAbs to fibrils anchoring hemidesmosomes

A

dermatitis herpetiformis

54
Q

IgA for gliadin attacks reticulin in dermal papillae fibrils

A

dermatitis herpetiformis

55
Q

dermatitis herpetiformis

A

rare
-males, 30-40yo

associated with celiac disease - anti-gliadin Abs**

intensely pruritic plaques and vesicles

56
Q

inflammation of subQ adipose tissue

A

panniculitis

septal or lobular**

57
Q

septal fatty inflammation

A

erythema nodosum

with infection

58
Q

lobular fatty inflammation

A

unknown etiology - possible fasculitis

59
Q

relapsing febrile nodular panniculitis in kids and adults

A

webere christain disease

MSK Exam 1 Spring 2015 (21 decks)

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