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MSK Exam 1 Spring 2015 > Skin Pathology I > Flashcards

Skin Pathology I Flashcards

1
Q

skin function

A 
protective covering - non-permeable
tactile interaction
body temp regulation
sexual attraction
immunity - APCs - langerhans epidermal dendritic cells
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2
Q

adnexa

A

pilar unit
eccrine unit
apocrine unit

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3
Q

two layers of dermis

A

papillary and reticular

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4
Q

layers of epidermis

A 
stratum corneum
stratum lucidum
stratum granulosum
stratum spinosum
stratum basale

DEJ - dermal epidermal junction

papillary dermis
reticular dermis

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5
Q

horny layer

A

stratum corneum

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6
Q

apocrine glands

A

deep dermis at junction of reticular dermis and subQ tissue

more in inguinal, axilla, scalp

more eosinophilic cytoplasm

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7
Q

melanocytes

A

supplies pigment to squamous cells

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8
Q

desmosomes

A

intercellular bridges

-tight junctions

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9
Q

papillary dermis

A

finely woven type I collagen parallel to surface

healing second intention

capillaries of superficial plexus - blushing/sunburn

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10
Q

basement membrane

A

defines invasion of cancer

  • proteins in blistering
  • and other inflammatory conditions
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11
Q

superficial vascular plexus

A

in papillary dermis

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12
Q

rete pegs

A

interlock with dermal papillae

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13
Q

pacinian corpuscle

A

pressure receptor

encapsulated nerve endings

found in deep dermis or hypodermis

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14
Q

meissner corpuscles

A

touch receptor

  • confined to dermal papillae
  • hands and feet more numerous
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15
Q

skin nerve supply

A

free nerve endings - detect pain and temperature

sympathetic innervation - blood flow and hair movement

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16
Q

subQ tissue

A

hypodermis

adipocytes - lobules
fibroconnective tissue - septae

also - lots of blood vessels - deep plexus

connects reticular dermis with fascia of underlying tissue**

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17
Q

lobular paniculitis

A

pancreatitis

fat in subQ

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18
Q

septal paniculitis

A

erythema nododum

fibrous in subQ

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19
Q

function of hypodermis

A

1 - body temp regulation - vascular and adipose

2 - fat storage

3 - aging

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20
Q

skin wrinkling

A

loss of subQ adipose tissue in hypodermis

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21
Q

intrinsic aging

A

wrinkles

basal layer proliferation and risk of neoplasm

decrease in melanocytes - whitening

decreased langerhans cells

thinning

also decreased hair shaft diameter, decreased # of hair follicles, and redistribution of hair

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22
Q

actinic degeneration of reticular dermis collagen

A

solar elastosis

telangiectasias - dilated vessels close to surface also occurs

23
Q

initial red with sunburn

A

vasodilation

24
Q

sunburn changes

A

increased blood flow to dermis

superficial vessels - endothelial swelling

perivenular edema

perivascular inflammatory infiltrate

25
Q

keratinocytes

A

squamous epithelial cells

26
Q

elevated fluid filled lesion more than 5mm

A

bulla

27
Q

linear traumatic epidermial disruption

A

excoriation

-deep scratch

28
Q

thick rogh skin with prominent skin markings

A

lichenification

-repeated rubbing

29
Q

flat circumscribed area 5mm or more that is colored

A

patch

30
Q

flat circumscribed area less than 5mm that is colored

A

macule

31
Q

separation of nail bed

A

onchyolysis

32
Q

elevated dome shaped lesion <5mm

A

papule

33
Q

elevated dome shaped lesion >5mm

A

nodule

34
Q

elevated flat top lesion >5mm

A

plaque

35
Q

discrete, pus-filled raised lesion

A

pustule

36
Q

dry, horny, platelike excrescence

-result of imperfect cornification

A

scale

37
Q

fluid filled raised lesion

A

bilster

38
Q

fluid filled lesion >5mm

A

bulla

39
Q

flui filled lesion >5mm

A

vesicle

40
Q

itchy, transient, elevated lesion with variable blanching and erythema formed as result of dermal edema

A

wheal

41
Q

loss of intercellular cohesion between keratinocytes

A

acantholysis

42
Q

diffuse epidermal hyperplasia

A

acanthosis

43
Q

abnormal, premature keratinization within cells below stratum granulosum

A

dyskeratosis

44
Q

loss of epidermis

A

erosion

45
Q

epidermal inflammatory cells

A

exocytosis

46
Q

intracellular keratinocyte edema

A

hydropic swelling - ballooning

often with viral infections

47
Q

Stratum granulosum hyperplasia, usually due to rubbing

A

hypergranulosis

48
Q

Stratum corneum thickening, often with aberrant keratinization

A

hyperkeratosis

49
Q

linear pattern of melanocyte proliferation within epidermal basal cell layer

A

lentiginous

50
Q

surface elevation caused by hyperplasia and enlargement of contiguous dermal papilla

A

papillomatosis

51
Q

keratinization with retained nuclei in stratum corneum

A

parakeratosis

normal in mucous membranes

52
Q

intercellular edema of epidermis

A

spongiosis

53
Q

discontinuity of skin showing complete loss of epidermis revealing dermis and subQ

A

ulceration

54
Q

formation of vacuoles with or adjacent to cells

A

vacuolization

MSK Exam 1 Spring 2015 (21 decks)

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