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msk exam 1 spring 2015 > NSAIDs > Flashcards

NSAIDs Flashcards

1
Q

acetylsalicycliac acid

A

ASA

-aspirin

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2
Q

propionic acid

A

iboprofen

naproxen

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3
Q

indoleacetic acid

A

indomethacin

etodolac

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4
Q

hereroaryl acetic acid

A

ketoralac

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5
Q

COX 2 selective NSAID

A

celecoxib

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6
Q

non-narcotic analgesic

A

acetaminophen

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7
Q

weak anti-inflammatory

A

acetaminophen

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8
Q

anti-inflammatory, analgesic, anti-pyretic

A

NSAIDs

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9
Q

analgesis, antipyretic

A

acetaminophen

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10
Q

NSAIDs MOA

A

inhibit COX - no PG synthesis

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11
Q

precursor to PG

A

arachidonic acid

free AA enters 1 of 2 pathways

  • COX - PG synthesis
  • lipoxygenase - leukotriene synthesis
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12
Q

COX1

A

most tissues present

housekeeping

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13
Q

COX2

A

undetectable in most tissue

increased during inflammation

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14
Q

irreversible inhibition of COX in platelets

A

aspirin

-used as anti-coag

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15
Q

analgesic effect

A

PGE2 sensitizes pain nerve endings

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16
Q

pyresis

A

cytokines, leukocytes, PGs in brain areas

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17
Q

vasodilation

A

PGE2 and PGI2

blocked by NSAIDs

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18
Q

apoptosis

A

PG inhibit apoptosis

NSAID - more apoptosis

used of NSAIDs and reduced risk of cancer

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19
Q

dose of aspirin for anticoag

A

low dose needed - 85-160mg/day

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20
Q

high dose aspirin

A

inhibit PGI2 - which is vasodilator and inhibitor of platelet

counterproductive for anticoag effect of aspirin

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21
Q

renal function and NSAIDs

A

decreased renal blood flow
decrease rate of glomerular filtration

can result - renal failure

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22
Q

reyes syndrome

A

CI for salicylates in children

with chicken pox of flu

23
Q

chicken pox or flu

A

no aspirin or other salicylates in children

use ibuprofen or naproxen instead

24
Q

NSAIDs other than aspirin

A

less side effect - particularly GI effects

25
Q

dysmennorhea

A

PG - cause cramping

NSAID tx

26
Q

closure of patent ductus arteriousus

A

indomethacin

27
Q

preeclampsia and HTN in pregnancy

A

low dose aspirin

28
Q

colorectal cancer

A

reduced risk with chronic aspirin use

29
Q

burn off warts

A

topical salicyclic acid

30
Q

NSAID pharmacokinetic

A

liver metabolism
kidney excretion

50-99% protein bound

31
Q

aspirin admin

A

should be take with food

-toxic to stomach lining

32
Q

analog of PGE1

A

misoprostol

-for chronic NSAID users

33
Q

CNS action of aspirin

A

due to salicylic acid

aspirin does not cross BBB

34
Q

low dose aspirin

A

retain uric acid

35
Q

high dose aspirin

A

excrete uric acid

36
Q

gout patient

A

should not use aspirin for analgesia - causes retaining of uric acid

37
Q

anti-platelet dose of aspirin

A

160mg/day

38
Q

analgesia/antipyretic aspirin

A

2600mg/day

39
Q

anti-inflammatory aspirin

A

4000mg/day

40
Q

toxic dose of salicylates

A

respiratory depression

41
Q

ringing in ears

A

sign of salicylism - mild salicylate intoxication

also - nausea, vomiting, hyperventilation, HA, mental confusion, dizzymnes

42
Q

third trimester of pregnancy

A

avoid aspirin and other NSAIDs

reduced birth weights

43
Q

naproxen

A

best tolerated

longer half life - less dosing through day

44
Q

tx rheumatoid arthritis, OA, ankylosing spondylitis, acute gout

A

indomethacin

45
Q

suppress contraction in preterm labor

A

indomethacin

46
Q

postop analgesia lasting 6-8 hours

A

etodolac

relatively COX2 selective

47
Q

NSAID IM or IV

A

ketorolac

limit to 5 days - because of GI toxicity

48
Q

selective COX2 inhibitor

A

celecoxib

49
Q

COX2

A

expressed constitituvely in brain and kidney

target for anti-inflammation

50
Q

COX1

A

in platelets

51
Q

weak anti-inflammatory

A

acetaminophen

only weak COX inhibitor

52
Q

acute overdose of acetaminophen

A

hepatotoxicity

53
Q

tx of acetaminophen toxicity

A

N-acetylcysteine - restore liver glutathione levels

54
Q

anti-leukotriene drugs

A

zafarlukast

montelukast

msk exam 1 spring 2015 (21 decks)

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