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MSK Exam 1 Spring 2015 > Joint and Soft Tissue Pathology II > Flashcards

Joint and Soft Tissue Pathology II Flashcards

1
Q

joint mice

A

calcium balls in joint space

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2
Q

ganglion cyst

A

near joint capsule or tendon sheath

  • common - around wrist
  • cystic or myxoid degeneration of CT
  • lacks cell lining

no communication with joint space

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3
Q

synovial cyst

A

herniation through joint capsule

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4
Q

synovial cyst forming in popliteal space in RA

A

baker cyst

herniation of cyst in knee

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5
Q

aspiration of ganglion cyst

A

thick/mucus

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6
Q

benign neoplasms in synovial lining ofjoints, tendon sheaths, and bursae

A

tenosynovial giant cell tumor

diffuse type and localized type

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7
Q

pigmented villonodular synovitis

A

diffuse tenosynovial giant cell tumor

large joints

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8
Q

giant cell tumor of tendon sheath

A

localized tenosynovial giant cell tumor

discrete nodule attached to tendon sheath in hand

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9
Q

tiger striped

A

tenosynovial giant cell tumor

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10
Q

below fascia

A

malignant

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11
Q

above fascia

A

benign

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12
Q

knee pain, locking, recurrent swelling, with palpable mass

A

diffuse tenosynovial giant cell tumor

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13
Q

soft tissue tumors

A

benign outnumber malignant

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14
Q

big lesion in thigh

A

think soft tissue neoplasm

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15
Q

t(11;22)

A

ewing sarcoma

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16
Q

spindle cells and groups of epithelioid cells - biphasic

A

synovial sarcoma

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17
Q

herring bone

A

fibrosarcoma

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18
Q

palisading - nuclei in columns

A

schwann cell

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19
Q

storiform - short fascicles of spindle cells from central point - spokes on a wheel

A

fibrohistiocytic

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20
Q

fascicles of eisinophils intersecting at right aingles

A

smooth muscle

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21
Q

benign tumor of fat

A

lipoma

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22
Q

most common soft tissue tumor of adulthood

A

lipoma

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23
Q

well encapsulated mass of adipocytes

A

lipoma

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24
Q

painful tumors

A

GLENDA

angiolipoma = A

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25
Q

soft, mobile, painless

A

lipoma

except angiolipoma - is painful

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26
Q

most common sarcoma of adulthood

A

liposarcoma

age 50-60yo

deep soft tissues

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27
Q

liposarcoma with abundant ground substance and rich capillary network with scattered immature adipocytes and stellate cells

28
Q

liposarcoma with mature adipocytes and scattered spindle cells

A

well-differentiated liposarcoma

29
Q

23yo F, soccer, hit in shin, develop swelling large mass week later

A

nodular fasciitis

30
Q

history of trauma

A

nodular fasciitis

31
Q

nodular fasciitis

A

fibroblastic and myofibroblastic proliferation typically in younger adults in upper extremity

with history of trauma**

32
Q

superficial fibromatosis

A

infiltrative fibroblastic proliferation that can cause local deformity

more in males

nodular or poorly defined broad fascicles of fibroblasts
surrounded by abundant dense collagen

33
Q

irregular thickening of palmar fascia

A

dupuytrens contracture

subtype of superficial fibromatosis

34
Q

peyronie disease

A

penile superficial fibromatosis

mass on dorsolateral aspect of penis
-eventual curvature of shaft

35
Q

subtypes of superficial fibromatosis

A

palmar
plantar
penile

36
Q

deep fibromatosis

A

desmoid tumor

large, infiltrative mass that frequently recur

no mets

teens to 30yo

in abdomen

37
Q

desmoid tumor

A

extra-abdominal- shoulder, chest wall, back, thigh
abdominal - anterior abdominal wall in women around pregnancy
intra-abdominal - mesentery or pelvic wall - individuals with familial adenomatous polyposis

38
Q

C section scar

A

turn to extra-abdominal desmoid tumor

39
Q

belly dancer

A

desmoid tumor - abdominal

40
Q

skeletal muscle tumors

A

almost all malignant**

41
Q

patient with TB

A

benign rhabdomyoma

42
Q

subtypes of rhabdomyosarcoma

A

alveolar - 20%
embryonal - 60%

pleomorphic - 20%

43
Q

alveolar rhabdomyosarcoma

44
Q

embryonal rhabdomyosarcoma

A

majority

kids

45
Q

pleomorphic rhabdomyosarcoma

46
Q

grape like

A

sarcoma botryoides

-embryonal rhabdomyosarcoma

47
Q

sarcoma botryoides

A

grape like

rhabdomyosarcoma

48
Q

cambium layer

A

submucosal zone of hypercellularity

-in embryonal rhabdomyosarcoma

49
Q

tx of rhabdomyosarcoma

A

aggressive

-surgery and chemo

50
Q

best prognosis rhabdomyosarcoma

A

embryonal rhabdomyosarcoma - botryoid variant

51
Q

pleomorphic rhabdomyosarcoma prognosis

52
Q

uterus

53
Q

benign smooth m tumor

A

leiomyoma

often in uterus

54
Q

arise of leiomyoma

A

often in erector pilar muscles
-pilar leiomyoma

may be multiple and painful

55
Q

volcano lesion

A

GIST tumor - c-kit positive

in stomach smooth m

56
Q

eosinophilic spindle cells in interweaving fascicles

A

leiomyosarcoma

57
Q

mets of leiomyosarcoma

58
Q

muscle specific actin immunostain

A

leiomyosarcoma

59
Q

synovial sarcoma

A

often around knee
-age 20-40yo

morph - monophasic or biphasic

60
Q

positive for epithelial markers - keratins

A

synovial sarcomas

61
Q

biphasic spindle cell and gland like histo appearnace

A

synovial sarcoma

62
Q

tx of synovial sarcoma

A

aggressive
-chemo and therapy

mets to lungs

63
Q

malignant fibrous histiocytoma

A

now called - undifferentiated pleomorphic sarcoma

64
Q

fascicles of plump spindle cells in swirling storiform pattern

A

pleomorphic fibrosarcoma

65
Q

herring bone pattern of malignant spindle cells

A

fibrosarcoma

66
Q

UPS

A

undifferentiated pleomorphic sarcoma

high grade pleomorphic cells cannot be classified into another category

largest category of adult sarcomas

aka - malignant fibrous histiocytoma - term no longer used

MSK Exam 1 Spring 2015 (21 decks)

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