Skin Pathology

Question 1

Neoplastic (4)

Answer 1

1. Benign Tumors
2. Basal Cell Carcinoma (BCC)
3. Squamous Cell Carcinoma (SCC)
4. Melanoma

Question 2

Benign Tumors

(2)

Answer 2

1. Nevus
2. Actinic Keratosis

Question 3

Nevus Mole

What is it?

Manifestation

Answer 3

“Melanocyte Nevus”

1. Benign Proliferation of melanocytes
2. Depends on location

Question 4

Nevus locatiointns

Answer 4

Junctional: at dermal-epidermal junction

Compound: into dermis

Inradermal: dermis only

Question 5

Actinic Keratosis

what is it?

Manifestation?

Answer 5

1. Benign neoplasm of epidermis
2. Rough Spots (less than 1cm) with erythematous bas on sun-exposed skin

Question 6

Actinic Keratosis if left untreated

Answer 6

Can become malignant (~10%)

Progressive Dysplasia of epidermis ( before squamous cancer)

Question 7

What causes Actinic Keratosis?

Answer 7

Sun exposed skin

ionizing radiation

Question 8

What is the most common tumor on sun exposed skin in older people?

Answer 8

Squamous cell carcinoma

Question 9

Squamous Cell Carcinoma

What is it?

Manifestation?

Answer 9

1. Malignant Tumor of Squamous Epithelium
2. Red Nodule

Question 10

If Squamous Cell Carcinoma metastasize…

Answer 10

<5%

poor prognosis

Invasive: invades the basement membrane and dermis

Question 11

Melanoma ABCDE

Answer 11

A- Aysmmetery

B- Border

C- Color

D- Diameter

E- Elevation

Question 12

Melanoma

What is it ?

Manifestation?

Answer 12

1. Malignant Tumor
2. ABCDE

Question 13

Melanoma can arrise from

Answer 13

benign nevus

Question 14

What increases the risk of Melanoma?

Answer 14

1. sun exposure
2. Familiy History
3. Multiple Benign Nevi larger than 6mm
4. History of sun burns

Question 15

Melanoma metastasizes

Answer 15

very lethal

Prognosis →depends on depth of invasion

Question 16

______ is the most important factor for Melanoma

Answer 16

Depth

Breslow’s Thickness

• <1 mm = 95-100% 5 year survival
• 1-2 mm = 80-96% 5 year survival
• 2-4 mm = 60-75% 5 year survival

Question 17

which form of Melanoma is the non-invasive skin growth that is considered melanoma-in-situ

Answer 17

Lentigo Maligna

Question 18

Acral Lentiginous Melanoma

(3)

Answer 18

1. Found on non-hair -bearing surfaces
2. Can be found in the oral Mucosa
3. Not Linked to Sun Exposure

Question 19

Warning sigins of Acral Lentiginous

Answer 19

new areas of pigmentation, or existing pigmentation that shows change

Question 20

Methods of diagnosis for melanomas

Answer 20

wedge biopsy/ punch biopsy