Inflammation and Repair

Question 1

Cells that mediate inflammatory processes

Answer 1

1. Monocyte
2. Lymphocte
3. Neutrophil
4. Eosinophil
5. Basophil

Question 2

Lymphocyte

Answer 2

Cell with a nucleus that mostly fills cellular space

Question 3

Neutrophil

Answer 3

polymorphonuclear leukocyte (PMN) cell with few granulocytes

Granulocyte

Question 4

Eosinophil

Answer 4

polymorphonuclear leukocyte (PMN) cell with many red granulocytes

Granulocyte

Question 5

Basophil

Answer 5

polymorphonuclear leukocytes (PMN) cell with many blue granulocytes

Granulocyte

Question 6

What do cells that mediate inflammatory response have in common?

Answer 6

1. Granulation
2. PMN

Question 7

Cellular Response

Answer 7

part of inflammatory response is delivery of leukocytes to injury

Question 8

How do Leukocytes get to the site of injury in acaute inflammation (cellular Response)?

Answer 8

1. Margination and rolling
2. Adhesion
3. Transmigration
4. Chemotaxis

Question 9

Neutrophil is the ____

Monocyte is the _____

Answer 9

First responder

Second Responder

Question 10

Once the Leukocyte destroys the pathogen …

Answer 10

1. Recognition and attachment to pathogen
2. Engulfment of pathogen
3. Killing and degradation of pathogen

Question 11

1.Recognition and attachment to pathogen

Answer 11

Pattern Recognition

Opsonins

Cytokine Receptors

Question 12

Monocyte

Answer 12

Large (oddly shaped) cell with a nucleus that does not fill cellular space

In blood→ monocyte in body→macrophage

Question 13

2. Engulfment of pathogen

Answer 13

When opsonins are sensed

Question 14

Celecoxib

Answer 14

Cyclooxygenase II inhibitor ( reduces inflammation)

Cyclooxygenase II meabolizes Arachidonic Acid to cause inflammation

Question 15

In chronic Inflammation

early following an injury, which macrophage predominates?

Answer 15

Alternatice Activation (M2)

Question 16

Monocytes in

Blood

Liver

Bone

Connective Tissue

Brain

Answer 16

Blood- Macrophage

Liver- Kupffer cell

Bone- Osteoclast

Connective Tissue- Histiocyte

Brain- Microglia

Question 17

What factors influence repair

Answer 17

1. Infection
2. Nutrition
3. Glucocorticoids
4. Poor perfusion
5. Foreign bodies
6. Location

Question 18

What are the two types of Repair?

Answer 18

1. Regeneration
2. Scar Formation

Question 19

Regeneration Repair

Answer 19

Tissue is able to replace the dmaged cells and return to normal function

Question 20

Scar Formation Repair

Answer 20

Layering of connective (scar) tissue as a less effective replacement for native tissue.

Question 21

Labile tissue …

Answer 21

have cells that are always proliferating

Question 22

incision wounds

Answer 22

longer that they are deep

Question 23

stab wound

Answer 23

deeper than the are long

Question 24

Puncture wounds

Answer 24

caused by sharp point, but not a sharp edge

Question 25

chopping wounds

Answer 25

combination of blunt and sharp characteristics

Question 26

Second intention wounds

Answer 26

healing wider wounds leads to scaring

Question 27

First Intention wounds

Answer 27

Healing Incision Wounds

leads to regeneration

Question 28

What happens of the INterstial Matrix/ISM is damaged?

Answer 28

Scar is formed

Question 29

Need an intact ISM/ Interstitial Matrix for…

Answer 29

regeneration

Question 30

scar formaiton repair steps

Answer 30

1. Angiogenesis- (No and VEGFS)
2. Migration and Proloferation- of fibroblasts and depostion of connective tissue (granulation tissue)
3. Remodeling to produce scar

Question 31

scar

Answer 31

more granulation tissue

Question 32

what are factors that infulence tissue repair

Answer 32

1. Infection
2. Nutrition
3. Glucocorticoids
4. Poor perfusion
5. Foreign Bodies
6. Location