skin immunology Flashcards
what function does the keratin layer/ epidermis have in skin defence and what proteins
physical lipid barrier, proteins: filaggrin, involucrin, keratin
what function does the keratinocytes have in skin defence, where are they, how do they initiate immune response
in epidermis activated by UV or pathogens and produce AMP’s, cytokines and chemokines
what function does the langerhans have in skin defence, where are they, how do they initiate immune response
prickle cell layer, they are main immune cells and are dendritic APC’s that produce Ag and present to effector T cells
what do langerhans have that make them identifiable
birbeck granules
what T cells are mainly in epidermis vs dermis
epidermis = CD8, dermis = CD4 and CD8 (NK’s also in both)
what CD4 T cell is associated with psoriasis
TH1
what CD4 T cell is associated with atopic dermatitis
TH2
what CD4 T cell is associated with psoriasis and atopic dermatitis
TH17
what do Th1 cells do and what are they activated by
activated by IL2, cause cellular disease (autoimunne) –> produces mainly macrophages
what do TH2 cells do and what are they activated by
activated by IL4, humeral response (allergies) –> activate B cells
what action does CD4+ have
once activated can become either Th1 or Th2 (activates B cells)
what action does CD8+ have
cytotoxic, direct cell killing
what immune cells are present in epidermis
Langerhans and T cells
what immune cells are present in dermis
dendritic (dermal and plasmacytoid), macrophages, NCK’s, T cells
where is MHC I present and what does it present to
on all cells CD8+T
