Psoriasis Flashcards
when keratinocytes are stressed what do they produce
IFNa and TNF
what TH is in psoriasis
1
TH1 cells secrete ____, which causes keratinocyte ____, ___ ____, ___ ____
IL 17, proliferation, AMP release, attracts neutrophils
what does dermal fibroblast release
growth factors
what does epidermal hyperplasia result in
increased epidermal turnover
what are some triggers of psoriasis
smoking, stress/ trauma, infection, HLA gene, ages 20’s and 50’s
what are the 4 main types of psoriasis
psoriasis vulgaris/ chronic plaque (most common), guttate (red, teardrop spots), palmoplantar pustular (palms and soles, smokers), erythrodermic (rare and everywhere, look like burns)
what is the main rash of psoriasis
patches of dry, red, scaly skin on extensors - scalp also affected
what are auspitz signs
tiny bleeding points when scale forcibly removed
what nail signs may be present
onycholysis (separation of nail from bed), pitting, dystrophy, subungual hyperkeratosis
what is always used in psoriasis treatment
emollients
what treatment is available for psoriasis (mild to severe)
coal tar, Vit D, dithranol, steroids, methotrexate, phototherapy
what are pros and cons of Vit D analogues and an example
calcipotriol, easy to apply but can be irritant. good for scalp or localised plaque
what are pros and cons of coal tar
for mild disease but messy and smelling
what are pros and cons of dithranol
effective but can stain normal skin and needs regular application throughout day
