photo dermatology Flashcards
what is photosensitivity
abnormal reaction to UV light
what is the management of photosensitivity
avoidance, suncream, phototherapy, inhibit mediator/ inflamm
what is a porphyria
enzyme deficiency in haem pathway that results in a build up of porphyrin
whats the difference between acute and cutaneous porphyria
acute mainly affects nervous system, cutaneous skin
in porphyria cutanea tarda (PCT) what is the enzyme and porphyria
uroporphyrinogen decarboxylase, uroporphyrinogen
who is most likely to have PCT
middle aged men
what are the symptoms of PCT
hyper-pigmentation, blisters on sun exposed sites, hypertrichosis (excessive hair), solar urticaria, morphoea (thick skin)
what can cause PCT
liver disease, alcohol, viral hepatitis, haemochromatosis
how do you investigate and treat PCT
wood lamps
low does antimalarials/ treat underlying
in erythropoietic protoporphyria what is the enzyme and porphyria
ferrochelatase, protoporphyrin (IX)
who is likely to have erythropoietic protoporphyria
children
what are the symptoms of erythropoietic protoporphyria
swelling/ itching, pain, burning - after minutes of UV exposure
what is the reduced enzyme in Acute intermittent porphyria
RBG deaminase
who gets Acute intermittent porphyria
females aged 30ish
what are the symptoms of Acute intermittent porphyria
no skin symptoms.
acute abdo pain, mood changes, seizures
