Skin and SQ Flashcards
Sabattini et al. p16 immunostaining of canine squamous cell carcinoma is not associated with papillomaviral DNA
Human oncognic PV increased expression p16 TSG
52 SCC
Immunoreactivity for p16?
No association with PV and p16
17% with no association with degeree of differentiation, histotype, mitotic activity
Munday et al. 2015. Molecular and immunohistochemical studies do not support a role for papillomavirus in canine oral SCC development
28 canine oral SCC
None of the primers amplified PV DNA, 4 contained intense p16 staining
Intense p16 staining - likely not due to PV due to lack of DNA
PVs are not significant cause of oral SCC
Nagamine et al. Invasive front grading and epithelial-mesenchymal transition in canine oral and cutaneous SCC
Most oral SCC were ___ than cutaneous SCC
Expression of E-cadherin, B-catenin, desmoglein was significantly ___ in oral SCC than cutaneous SCC
Association was found between invasive front grading and?
E-cadherin, B-catenin, desmoglein predict biological behaivour of canine SCC
higher histologic grade
lower
loss of E-cad, B-catenin, desmoglein
Millanta et al. Correlation between COX-2 and VEGF expression in canine and feline SCC
51 canine and feline cutaneous and non-cutanoeus SCC
COX-2 expression in canine and feline SCC?
Expression was higher in ____ than ___ SCC
COX2 and VEGF were correlated with progression of disease, but no with lymphatic invasion, tumor grading, or tumor classification in cuteanous tumors
53% and 61%
Cutaneous than non-cutaneous
Belluco et al. 2013. Digital SCC in dogs: epidemiological, histological, and immunohistochemical study
The mean was?
Dark-haired animals comprosed?
Large and giant breeds?
Which limb was more affected?
10 years
92%
75%
Fore limb twice more than hind limb
Dohata et al. 2015. Clinical and pathologic study if feline merkel cell carcinoma with immunohistochemical characterization of normal and noeplastc merkel cells
Merkel cells were positive for CK20, CK18, p63, NSE, synaptophysin, protein gene product 9.5
Tumor cells were positive for CK20, CK18, p63, NSE, and synaptophysin
