Ocular Flashcards
Pinard et al. Retrospective study and review of ocular radiation side effects following external-beam Cobalt-60n radiation therapy in 37 dogs and 12 cats
60Gy in 24 fraction for cutartive intent or 8 Gy in 1 fraction for palliative treatment
Main ocular side effect reported in dogs and cats?
Other ocular side effects?
Conjunctivitis (79% and 55%)
Eyelid lesions in dogs (44%), ulcerative keratitis in cats (36%), LCS in dogs and cats (44% and 27%)
Need for regular ophthalmic examination as follow up with RT
McCowan et al. Conjunctival LSA: immunophenotype and outcome in 5 dogs and 3 cats
Systemic disease?
Immunophenotype for dogs? cats?
Outcome?
1 dog had generalized lymphadenopathy but others so detectable disease beyond the eye
T-cell tumors and B-cell tumors
3 dogs euthanized within 6 months, other 2 had no systemic disease. 2 cats good survival following diagnosis, other died of lesions that may not be related
Nerschbach et al. Ocular manifestation of LSA in newly diagnsoed cats
26 cats
Ocular involvement noted in?
Most common ocular findings?
8 cats received chemotherapy - 2 had ocular involvement, response noted?
Due to ocular involvement, ____ occured from ___
48%
Unveitis anterior and posterior 58% - exophthalmos, corneal surface lesions, and chemosis
CR of anterior and PR of posterior uveitis
Stage migration from Stage IV to V in 4 patients
Ota-kuroki et al. Intraocular and periocular LSA in dogs and cats: a retrospective review of 21 cases (2001-2012)
6 canine and 15 feline ocular LSA
Canine and feline intraocular and periocular LSA are what phenotype?
B cell
Lederer et al. Differentiation between inflammatory and neoplastic orbital conditions based on CT signs
Level of agreement between observers between the presence or absence of abnormal CT signs with orbital disease?
Highest concerning for?
Associaion between abnormal structures and neoplasia?
Inflammatory disease
Poor to moderate
Orbtial bones and involvement of posterior segment
Abnormalities affecting orbital bones and anterior ocular structures
Abnormalities affecting extraconal fat and skin
Dustin Dees et al. Third eyelid gland neoplasms of dogs and cats: a retrospective histopathologic study of 145 cases
127 canine and 18 feline cases
Most common canine TEL gland tumor?
How many canine had metastatic disease? local recurrence?
Most common feline TEL gland tumor?
How many feline had metastatic disease? local recurrence?
ACA (85%), adenoma (14.2%), SCC (0.8%)
8.1%, 11.3%
ACA (83.3%), SCC (16.7%)
40%, 30%
Scott et al. Canine orbital rhabbomyosarcoma: a report of 18 cases
Age of dogs?
CS?
US done in 9 cases revealed?
Advanced imaging in 9 cases?
Histologically classified as?
IHC labeling for desmin? SMA?
Older dogs?
Young dogs?
Young, median 2 years
Exopthalmos (16/18) with dorsolateral deviation of the globe (10/18) and elevation of nictitans (12/18)
Orbital mass with mixed echogeneicity and posterior globe indentation
Soft tissue mass with variable contrast enhacement and lysis of orbital bones (5/9)
Embryonal rhabdomyosarcoma
All positive, 14/18 positive for SMA
No clinical signs of recurrence of metastasis 8-13 monsthe post diagnosis
Euthanized within 6 months of diagnosis due to recurrence and/or metastasis
Komnenou et el. Ocular manifestation of canine TVT: a retrospective study of 25 cases in Greece
TVT ocular lesions were unilateral (21 dogs) or bilateral (4 dogs)
Masses were noted on bulbar conjunctiva of nictitating membrane in 17 dogs, conjunctiva of upper eyelid in 5 dogs and on conjunctiva of lower eyelid in 3 dogs
Deep ulcerative keratitis in 8 animals
Large eye masses surgically excised, All dogs treated with vincristine. After 4 weeks complete resolution in all but 1.
Regan et al. Primary primitive neuroectodermal tumors of the retinal and ciliary body in dogs
Beckwith-Cohen et al. Squamous papillomas of the conjunctiva in dogs: a condition not associated with papillomaviris infection
Conjunctival squamous papilloma - Appear exophytic, papilliferous, pedunculated lesions with delicate fronds and angular ternubak margins
Squamous papillomas presented with delicate fibrovascular core and assciated with clinically and grossly with a feeder vessel
Conjunctival squamous papilloma resembled squamous papiloma of the skin but lacked hyperkeratosis
Compared with conjunctival papilomas these occured in older dogs and were smaller and solitary
PCR - no papillomavirus genetic material in conjunctival squamous papillomas
Nonviral and viral conjunctival papillomas were considered benign
Ravi et al. Clinical, morphologic, and immunohistochemical features of canine orbital hibernomas
Hibernomas are benign tumors of brown fat
Age and breed predilection?
Mean age?
Soft lobular masses composed of predominantly round or polygonal neoplastic cells with granular eosinophilic and vacoulated cytoplasm
IHC positive for?
Rare cells also expressed?
Older dogs and no breed predilection
10.4 years
UCP-1 (uncoupling protein 1) - brown fat differentiation
Myogenin and myoD - common progenitor cells for neoplastic brown adipose and skeletal muscle cells
Rushton et al. 2018. Circulating cell-free DNA does not harbor a diagnostic benefit in cats with feline diffuse iris melanomas (FDIM)
FDIM is most common malignant primary intraocular tumor in cats - metastasis 19-63%
No significant differences between cats with iris melanoma, irus naevus or the control group
Cats with metastases showed similar cfDNA concentration and integrity to cats without metastases
