Skeletal System Flashcards
functions of skeletal system
support of body
protection of internal organs
levers for skeletal muscles to act
production of blood cells through bone marrow
storage of minerals
bone composition
composite material
- 70% calcium phosphate crystals (inorganic)
- 30% collagen fibres (organic)
remodels under influence of forces
calcium phosphate
strong but inflexible
ability to resist compressive stress
collagen
tough + flexible
ability to resist stretching, bending, + twisting stresses
anisotropic
bone (and wood) has different strength and hardness properties depending on its orientation
→ properties are different in different planes
mesenchymal cells
stem cells
undifferentiated
osteoprogenitor cells
stem cells - unspecialized mesenchymal cells
found in outer + inner layers of bone
differentiate into more specialized bone cells → osteoblasts
important role in fracture repair
osteoblasts
bone cells derived from osteoprogenitor cells
secrete osteoid
‘bone-producing cells’
osteocytes
osteoblasts that become trapped in hard bony tissue
mature bone cells
monitor + maintain protein levels + mineral contents of bony matrix
osteoclasts
large multinucleated bone cells
derived from precursor blood cells
secrete acids that erode bony matrix for release of amino acids + minerals in body fluids (blood)
osteiod
collageous material secreted from osteoblasts
unmineralized bone → will mineralize (calcify) to become bone
compact bone
relatively dense + solid
mainly found in diaphyses of long bones
spongy (trabecular) bone
open network of struts + plates
composed of trabeculae
interior bone tissue of short, flat, + irregular bones; epiphyses in long bones
endosteum
single layer of osteoblasts + fibrous tissue
inner layer (deeper tissue) lining medullary cavity
periosteum
single layer of osteoblasts + fibrous tissue
top outer layer (transparent)
medullary cavity
yellow marrow (adipocytes - fat)
+ red marrow (mature + immature red + white blood cells)
osteon
basic functional unit of mature compact bone
made up of Haversian systems: osteocytes organized in concentric layers around a central canal containing blood vessels
lamellae
parallel alignment of collagen into sheets to form calcified extracellular matrix
- concentric: concentric rings that form osteons
- circumferential: rings that line inner + outer surfaces of compact bone
- interstitial: areas of incomplete lamellae between osteons
lacunae
cavities between lamellae that contain osteocytes
trabeculae
irregular lattice arrangement of lamellae that surround red bone marrow
cartilage
type of connective tissue
dense network of collagen or elastic fibres
chondroblasts
deposit cartilage extracellular matrix
mature into chondrocytes
chondrocytes
sit in lacunae
found in cartilage
perichondrium
connective tissue covering surface of most cartilage
bone matrix
organic osteoid + inorganic hydroxyapatite (calcium phosphate + carbonate)
intramembranous ossification
develops from fibrous membrane
forms directly in mesenchyme
flat bones of skull + clavicle
- ossification centre
- calcification of matrix
- formation of trabeculae
- development of periosteum
ossification centre
deep inside membranous tissue
between periosteum and bone; where bone growth occurs
crowding of mesenchymal cells
endochondral ossification
bone replaces cartilage
in long bones
condensation of mesenchymal cells
growth
formation of primary + secondary ossification centres
interstitial growth
increase bone length
growth from within model
chondrocytes → cell division
secretion of more extracellular matrix
appositional growth
increase bone width
development of new chondrocytes from perichondrium → secrete new matrix
diaphysis
shaft of long bone
site of primary ossification centre
epiphysis
ends of long bone
site of secondary ossification centres
metaphysis
growth plates
junction between diaphysis and epiphyses where hyaline cartilage persists
resorption
local removal of bone + remodeling of bone surface by osteoclasts
decrease of bone width from inside
bone strength
orientation of stress influences bone’s ability to resist the stress
compression
push two ends together
bone is best at resisting
200 MN/m2 required to break
tension
pulling two ends apart
~135 MN/m2 required to break
shear
twisting to ends in opposite directions
easiest to break bone
~70 MN/m2 required to break
bone repair
- fracture hematoma formation
- fibrocartilaginous callus formation
- bony callus formation
- bone remodelling
bone remodeling
similar to appositional growth
balance between resorption + deposition of osteoclasts and osteoblasts
bone aging
hormonal changes affects balance between osteoblasts + osteoclasts
leads to osteoporosis
↓ ability of strain to resist stress = easier to break
osteoporosis
bone loss = low bone density
changes ability of bone to resist stress
long bone
ex. humerus
flat bone
ex. skull bones
two thin plates of compact bone separated by spongy bone
pneumatized bone
ex. ethmoid
air chambers within bone
irregular bone
ex. vertebrae
short bone
ex. carpal bones
bony features
elevations + projections
openings
processes for attachment
processes for articulation
depressions
crest
narrow prominent ridge
spine
sharp, pointed, narrow process
line
slightly raised, elongated, low ridge
trochanter
large rough projection
two massive bony processes on femur
tubercle
small rounded projection