Nervous System Flashcards
nervous system
CNS + PNS
CNS
brain + spinal cord
brain
forebrain
midbrain
hindbrain
PNS
cranial nerves
spinal nerves
peripheral ganglia
somatic + autonomic
SNS
motor + sensory
control of body wall + upper/lower extremities
ANS
visceral
motor + sensory
motor → symp. + parasymp
cells in NS
neurons: nerve cells that conduct signals
neuroglia: support cells for neurons
neuron
~ 100 billion neurons (10^11)
each one has ~ 100 000 connections with other neurons
cell body = nucleus, nucleolus, dendrites, mitochondria, Nissl bodies
1 axon leaves cell body
synapse
connections between neurons
10^15 in CNS
nerve cell bodies
nucleus: collection in CNS
ganglia: collection in PNS
Nissl bodies
specialized ribosomal bodies
specific to nerve cells
neurofibrils
intermediate filament proteins
provide support within axon hillock
axon hillock
initial segment
summation of excitatory + inhibitory input
if threshold potential is reached = fires
bipolar neuron
2 appendages = 1 dendrite + 1 axon
senses = vision, taste, olfaction
unipolar neuron
1 appendage
somatosensation (afferents)
multipolar neuron
many dendrites, one axon
efferents (motor)
pyramidal, purkinje, stellate, granule, basket cells → found in brain = different dendrite branching
satellite cells
neuroglia that surround cell bodies in ganglia (PNS)
regulate O2, CO2, nutrient, + NT levels around neurons
Schwann cells
neuroglia that surround axons in PNS
one cell wraps one section of axon + produces myelin sheath = participate in repair process after injury
oligodendrocytes
neuroglia that myelinate CNS axons
have appendages = one cell myelinates many whole axons
provides structural framework
astrocytes
neuroglia in CNS
provide structural support; regulate ion, nutrient, + dissolved gas concentrations; absorb + recycle NT; form scar tissue after injury
some maintain blood-brain barrier
ependymal cells
neuroglia in CNS
line ventricles + spinal cavity
assist in producing, circulating, and monitoring of CSF
microglia
neuroglia in CNS
circulate to remove cell debris, wasts, and pathogens by phagocytosis (substitute for blood = limited by BBB)
meninges
membranes covering CNS structures = protection
- dura mater: tough outer layer; protect from external force
- arachnoid mater: secretes CSF into subarachnoid space; covers cranial blood vessels
- pia mater: delicate covering of brain
cerebrum
higher cognitive functions
language + speech
somatic motor + sensory function
regulates emotional aspects of behaviour
cerebral cortex
outside surface
grey matter
neuronal cell bodies
cerebral medulla
inner region
white matter
axons
longitudinal fissure
interhemispheric
separates L + R hemispheres
poles of cerebrum
frontal pole
occipital pole
2 temporal poles (L+R)
sulci
central sulcus = separates pre + post central gyri
lateral sulcus = separates temporal lobe
frontal lobe
higher cognitive planning, strategy, motor
parietal lobe
perception of self in space, sensory
temporal lobe
memory, learning, social, hearing
occipital lobe
vision = most important sense
precentral gyrus
frontal lobe
primary motor cortex = initiation of motor signals
- motor homunculus - map on cortex corresponding to body
anterior to central sulcus
postcentral gyrus
parietal lobe
primary sensory cortex
- sensory homunculus - map on cortex corresponding to body
posterior to central sulcus
projection fibres
travel to and from cortex
ex. to/from spinal cord
association fibres
intrahemispheric connections
- short ex. within lobe
- long ex. between lobes → BA to WA for speech
commissural fibres
interhemispheric connections
ex. corpus callosum = largest
cerebellum
acts as a comparator = compares intended movement with evolving movement and corrects for errors → uses feedback to make adjustments
ensures movements are smooth, coordinated, and purposeful (skilled)
regulates posture + balance
cerebellar ataxia
intention tremor, lack of balance + coordination
brainstem
midbrain, pons, medulla oblongata
contains motor + sensory pathways connecting cerebral cortex + thalamus to SC
houses cranial nerve nuclei (origins of CNs)
contains RAS = arousal + consciousness
vital centres for regulating heart rate + breathing
centres for regulating swallowing + gag reflex
diencephalon
thalamus: inferior to corpus callosum; bilateral structure
hypothalamus: inferior to thalamus
midbrain
substantia nigra + red nucleus
relay centres for visual and auditory pathways (reflexive orientation)
CNs III + IV attached
substantia nigra
regulates motor activity
neuronal degeneration = Parkinson’s disease
red nucleus
regulates motor activity
active controller of flexors of upper extremities
controlled by descending inhibition
pons
bridge between cerebrum + cerebellum
CNs V, VI, VII, VIII attached
medulla oblongata
contains vital cardio-respiratory regulatory centres
nuclei for CNs IX, X, XI, XII
ventricles
lumen of neural tube during development
fluid from capillary beds = CSF → circulates within brain
lateral ventricles
have anterior + posterior horns
connect to 3rd ventricle
3rd ventricle
separates L + R thalamus
feeds into cerebral aqueduct = connects to 4th ventricle
4th ventricle
between pons and cerebellum
feeds into central canal within SC
internal carotid arteries
paired
ascend carotid canals
divide into anterior + middle cerebral arteries
vertebral arteries
branch from subclavian arteries
ascends through foramen magnum
L+R join at pons → basilar artery → posterior cerebral arteries
anterior cerebral artery
branches from internal carotid, forms anterior of Circle of Willis
supplies medial + dorsal brain
anterior communicating artery
bridges L+R anterior cerebral arteries
middle cerebral artery
from internal carotid, extends laterally
supplies lateral brain
posterior cerebral artery
from basilar, extends laterally
forms posterior of Circle of Willis
supplies posterior and ventral brain
posterior communicating arteries
connects posterior + middle cerebral arteries (2; one on each side)
forms sides of Circle of Willis
spinal cord
within vertebral column
projection pathway to/from cerebral cortex; extends from medulla at foramen magnum
ends as conus medullaris at L1-2 intervertebral disc
bulges in lower cervical (brachial plexus) + lumbar (lumbosacral plexus) segments = roots of spinal nerves for upper/lower extremities
central canal
within SC; passes through centre of grey matter
continuous with ventricles of brain
cauda equina
nerve roots extending from SC; lie inferior
growth to maintain attachment between SC and vertebral column during development (VC grows faster)
filum terminale
pia matter continues past SC
attaches cord to coccyx = stabilizing
ends at S2 vertebral level
spinal cord organization
inner grey matter
- dorsal (sensory) horn → dorsal root
- ventral (motor) horn → ventral root
outer white matter = axon tracts
dorsal + ventral roots join = spinal nerve
posterior median sulcus; anterior median fissure
sensory + motor info
continuous flow between brain, SC, peripheral nerves + organ systems
millions of neurons deliver incoming + outgoing info
pathways between CNS + PNS
ascending + descending
consists of a chain of neurons + associated cell bodies (nuclei or ganglia)
somatic sensory pathways
dorsal column/medial lemniscal
spinothalamic
spinocerebellar
dorsal columns
proprioception + discriminant touch
receptor → 1st order neuron ascends ipsilaterally → medulla = synapse on 2nd order neuron → crosses in brainstem
fasciculus cuneatus
upper dorsal column
formed by upper extremities + trunk
corresponds to nucleus cuneatus in midbrain