Skeletal muscle relaxants

Question 1

Competitive antagonist at Nm receptor at the neuromuscular junction

Answer 1

Curare drugs

Question 2

Hofmann elimination

Answer 2

Spontaneous, nonenzymatic degradation in plasma and tissue

Atracurium and cisatracurium

Question 3

Drug interaction with succinylcholine that worsen its affect

Answer 3

Sevoflurane
Aminoglycosides
Tetracycline
Ca channel blockers

Question 4

Agent to administer to reduce the potentiation affect of sevoflurane(inhalational anesthetic) and curare drugs

Answer 4

Neostigmine - a cholinesterase inhibitor

Question 5

Agent to administer to reduce the potentiation affect of certain antibiotics with curare drugs

Answer 5

Sugammadex

Question 6

Mechanism of action of Sugammadex

Answer 6

Form a tight, inactive compound with curare drugs

Question 7

Side effects of succinylcholine

Answer 7

Prolonged apnea
Hyperkalemia
Postop myalgia
Malignant hyperthermia

Question 8

Cause of malignant hyperthermia

Answer 8

Autosomal dominant abnormal RyR1 Ca channel in SR

Question 9

Complications of malignant hyperthermia

Answer 9

Rhabdomyolysis
Renal failure

Question 10

Treatment for malignant hyperthermia

Answer 10

Dantrolene
Bicarbonate
Rapid external cooling
O2 inhalation

Question 11

What type of receptor GABA-b?

Answer 11

GPCR - Gi

Question 12

GABA-b receptor agonist drug

Answer 12

Baclofen

Question 13

Centrally acting alpha-2-adenoceptor agonist drug

Answer 13

Tizanidine

Question 14

Drug that blocks the release of ACH from presynaptic nerve at muscle end plate junction causing muscle paralysis

Answer 14

Botulinum toxin A

Question 15

Antispastic agents that can relieve acute muscle spasm locally, but is not effective in CNS diseases

Answer 15

Cyclobenzaprine
Orphenadrine
Chlorzoxazone
Methocarbamol

Question 16

Peripheral skeletal muscle relaxations

Answer 16

Dantrolene
Tubacurarine
Atracurium
Succinylcholine