Pharm - metabolic disease of bone

Question 1

Form of calcium that does not depend on stomach’s acidity for digestion

Answer 1

Calcium citrate

Question 2

Calcium decreases the absorption of these drugs

Answer 2

Ciprofloxacin
Fluoride
Phenytoin
Levothyroxine
Tetracycline

Question 3

Drug that inhibits absorption of vit D

Answer 3

Cholestyramine

Question 4

Drugs that increase the metabolism of vit D

Answer 4

Phenytoin
Barbiturates

Question 5

Drug class that inhibit bone resorption by osteoclasts by being deposited in bone with hydroxyapatite

Answer 5

Bisphosphonates

Question 6

Adverse affects of bisphosphonates

Answer 6

GI distress
Esophageal erosion if PO
Osteonecrosis of jaw
Atypical femur fractures with long-term use

Question 7

Drug interaction of bisphosphonates

Answer 7

Calcium supplements and antacids decrease absorption

Question 8

Drug that acts by stimulating bone formation by osteoblasts

Answer 8

Teriparatide

Question 9

IgGr monoclonal antibody of RANKL that inhibits bone resorption by osteoclasts

Answer 9

Denosumab

Question 10

Adverse effects of denosumab

Answer 10

Muscle and joint pain
Skin and soft tissue infections
Osteonecrosis of jaw

Question 11

Drug that is an analog of a substance secreted by parafollicular cells of thyroid that works by inhibiting bone resorption by osteoclasts

Answer 11

Calcitonin

Question 12

Uses of calcitonin

Answer 12

Osteoporosis
Paget disease
Hypercalcemia

Question 13

Risks associated with high-dose estrogen

Answer 13

Breast cancer
Thromboembolic disorders

Question 14

Selective estrogen receptor modulator that inhibits bone resorption by osteoclasts

Answer 14

Raloxifene

Question 15

Adverse effects of raloxifene

Answer 15

Hot flashes
Stroke, PE, and DVT

Question 16

Drug that has a dual mechanism of inhibiting bone resorption and increasing bone formation. It is not approved for use in US

Answer 16

Strontium