Diseases of the joint Flashcards
Characterized by cartilage degeneration and fibrillation that results in structural and functional failure of synovial joints
Osteoarthritis
Lesions stem form degeneration of the articular cartilage and disordered repair
Osteoarthritis
Associated with fibrillation of cartilage and subchondral cyts
Osteoarthritis
Heberden nodes
Bone excrescences at the DIP
Bouchard nodes
Bone excrescences at PIP
Characteristic fissuring, flaking, and erosion of cartilage microscopically
Osteoarthritis
Symmetric polyarthritis with nonsuppurative proliferative and inflammatory synovitis
RA
Pathogenesis of RA
CD4+ helper T cell initiate autoimmune response against self-antigens
Major cytokine mediators involved in RA
IFN-gamma
IL-17
RANKL
TNF
IL-1
Edematous, thickened, and hyperplastic synovium
RA
Pannus
Mass of edematous synovium, inflammatory cells, granulation tissue, and fibroblasts in RA
Central zone of fibroid necrosis surrounded by a prominent rim of activated macrophages, lymphocytes, and plasma cells
Rheumatoid nodules
Boutonniere deformity
PIP flexion and DIP extension in RA
Swan neck deformity
PIP hyperextension and DIP flexion
Radiograph shows joint effusions, juxta-articular osteopenia with erosions, narrowing of joint space, loss of articular cartilage, and carpal crowding at wrist
RA