Diseases of the joint Flashcards

1
Q

Characterized by cartilage degeneration and fibrillation that results in structural and functional failure of synovial joints

A

Osteoarthritis

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2
Q

Lesions stem form degeneration of the articular cartilage and disordered repair

A

Osteoarthritis

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3
Q

Associated with fibrillation of cartilage and subchondral cyts

A

Osteoarthritis

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4
Q

Heberden nodes

A

Bone excrescences at the DIP

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5
Q

Bouchard nodes

A

Bone excrescences at PIP

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6
Q

Characteristic fissuring, flaking, and erosion of cartilage microscopically

A

Osteoarthritis

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7
Q

Symmetric polyarthritis with nonsuppurative proliferative and inflammatory synovitis

A

RA

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8
Q

Pathogenesis of RA

A

CD4+ helper T cell initiate autoimmune response against self-antigens

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9
Q

Major cytokine mediators involved in RA

A

IFN-gamma
IL-17
RANKL
TNF
IL-1

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10
Q

Edematous, thickened, and hyperplastic synovium

A

RA

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11
Q

Pannus

A

Mass of edematous synovium, inflammatory cells, granulation tissue, and fibroblasts in RA

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12
Q

Central zone of fibroid necrosis surrounded by a prominent rim of activated macrophages, lymphocytes, and plasma cells

A

Rheumatoid nodules

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13
Q

Boutonniere deformity

A

PIP flexion and DIP extension in RA

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14
Q

Swan neck deformity

A

PIP hyperextension and DIP flexion

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15
Q

Radiograph shows joint effusions, juxta-articular osteopenia with erosions, narrowing of joint space, loss of articular cartilage, and carpal crowding at wrist

A

RA

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16
Q

Specific marker for RA

A

Anti-citrullinated peptide antibodies

17
Q

IgM and IgA autoantibodies that bind to IgG Fc regions

A

Rheumatoid factor

18
Q

Genetic allele seen in many pts with RA

A

HLA-DRB1

19
Q

Felty syndrome

A

Splenomegaly, neutropenia, and RA

20
Q

Severe destructive arthropathy in joint deprived of pain and position sense

A

Neuropathic joint disease or Charcot’s joint

21
Q

X-ray shows either bone resorption or new bone formation with bone dislocation and fragmentation

A

Charcot’s joint

22
Q

Oligoarthritis of large joints with a positive ANA in children

A

Juvenile idiopathic arthritis

23
Q

Heterogenous groups of disorders characterized by absence of RF, pathologic changes of ligamentous attachments, SI joint involvement, and HLA-B27.

A

Seronegative spondyloarthropathies

24
Q

Increased IF-alpha, IL-6, TNF-alpha, and inflammatory markers recruit T cells into skin and joint

A

Psoriasis and psoriatic athritis

25
Q

Asymmetric joint involvement including DIP and spine with joint stiffness in the morning. Dactylitis is also seen.

A

Psoriatic arthritis

26
Q

Other conditions seen in psoriasis and psoriatic arthritis

A

Uveitis
Sacroiliitis

27
Q

Chronic inflammatory disorder that causes destruction of articular cartilage and bone ankyloses that primarily involves SI joint and spine

A

Ankylosing spondylitis

28
Q

Allele associated with 90% of ankylosing spondylitis

A

HLA-B27

29
Q

Conditions associated with ankylosing spondylosis

A

Aortitis with regurgitation
Anterior uveitis
Restrictive lung disease

30
Q

Positive Schober test

A

Limited spine flexibility in ankylosing spondylitis

31
Q

Radiographic characteristic of ankylosing spondylitis

A

Bamboo spine due to vertebral body fusion

32
Q

Triad in reactive arthritis

A

Mono or oligo arthritis
Nongonococcal urethritis or cervicitis
Conjunctivitis

33
Q

Circinate balanitis

A

Shallow ulcerations on distal shaft and glans of penis, associated with reactive arthritis

34
Q

Keratoderma blennorrhagicum

A

Yellow-brown vesico-pustular lesions lesion associated with reactive arthritis

35
Q

Ossification at tendo-ligamentous insertion sites and development of calcaneal spurs and bony outgrowths

A

Reactive arthritis