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Human basic neuroscience > Signal Transduction: From Receptor to Second Messenger > Flashcards

Signal Transduction: From Receptor to Second Messenger Flashcards

1
Q

Stimulation of which receptors increases phospholipase C? (Select 2.)

A

Study on!

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2
Q

In the last 2 questions, we examined the big picture and types of receptors. Now let’s connect each receptor to its effector and second messenger.

A

Let’s do it!!!

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3
Q

The alpha 1 receptor is associated with a —– protein for signal transduction

A

Gq

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4
Q

The alpha 2 receptor is associated with a —– protein for signal transduction

A

Gi

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5
Q

The beta 1 and beta 2 receptors are associated with a —– protein for signal transduction

A

Gs

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6
Q

The Nicotinic receptors in the ANS ganglia, NMJ & CNS are associated with —— for signal transduction

A

Ions channels

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7
Q

The Muscarinic 1/3/5 receptors are associated with a —– protein for signal transduction

A

Gq

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8
Q

The Muscarinic 2/4 receptors are associated with a —– protein for signal transduction

A

Gi

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9
Q

The Dopamine 1 (postsynaptic) receptor is associated with a —– protein for signal transduction

A

Gs

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10
Q

The Dopamine 2 (presynaptic) receptor is associated with a —– protein for signal transduction

A

Gi

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11
Q

The Vasopressin 1 (vasculature) receptor is associated with a —– protein for signal transduction

A

Gq

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12
Q

The Vasopressin 2 (renal tubules) receptor is associated with a —– protein for signal transduction

A

Gs

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13
Q

The Histamine 1 receptor is associated with a —– protein for signal transduction

A

Gq

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14
Q

The Histamine 2 receptor is associated with a —– protein for signal transduction

A

Gs

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15
Q

Activation of the Alpha 1 receptor (Gq) will turn on —–.

A

Phospholipase C

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16
Q

Activation of the Alpha 2 receptor (Gi) will turn off —–.

A

Adenylate cyclase

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17
Q

Activation of the beta 1 and beta 2 receptors (Gs) will turn on —–.

A

Adenylate cyclase

18
Q

Activation of the Muscarinic 1/3/5 receptors (Gq) will turn ON —–.

A

Phospholipase C

19
Q

Activation of the Muscarinic 2/4 receptors (Gi) will turn OFF —–.

A

Adenylate cyclase

20
Q

Activation of the Dopamine 1 (postsynaptic) receptor (Gs) will turn ON —–.

A

Adenylate cyclase

21
Q

Activation of the Dopamine 2 (presynaptic) receptor (Gi) will turn OFF —–.

A

Adenylate cyclase

22
Q

Activation of the Vasopressin 1 (vasculature) receptor (Gq) will turn ON —–.

A

Phospholipase C

23
Q

Activation of the Vasopressin 2 (renal tubules) receptor (Gs) will turn ON —–.

A

Adenylate cyclase

24
Q

Activation of the Histamine 1 receptor (Gq) will turn ON —–.

A

Phospholipase C

25
Q

Activation of the Histamine 2 receptor (Gq) will turn ON —–.

A

Adenylate cyclase

26
Q

In general, activation of a receptor coupled to a Gq protein will turn ON —–.

A

Phospholipase C

27
Q

In general, activation of a receptor coupled to a Gs protein will turn ON —–.

A

Adenylate cyclase

28
Q

In general, activation of a receptor coupled to a Gi protein will turn OFF —–.

A

Adenylate cyclase

29
Q

—–, —–, and —– are the 3 second messengers that are activated when Phospholipase C is turned ON

A

IP3, DAG, Ca+2

30
Q

—– is the second messenger that is activated when Adenylate cyclase is turned ON

31
Q

—– is the second messenger that is deactivated when Adenylate cyclase is turned OFF

32
Q

IP3 =

A

Inositol trisphosphate

33
Q

DAG =

A

Diacylglycerol

34
Q

cAMP =

A

Cyclic adenosine monophosphate

35
Q

Remember that the cellular response is —– specific

A

Tissue-specific

36
Q

Which receptors are coupled to a Gq protein?

A

alpha 1

M1, 3, 5

V1

H1

37
Q

Which receptors are coupled to a Gi protein?

A

alpha 2

M2, 4

D2

38
Q

Which receptors are coupled to a Gs protein?

A

beta 1, 2

D1

V2

H2

39
Q

Stimulation of which receptors increases phospholipase C? (Select 2.)

A

Alpha-1

Vasopressin-1

40
Q

References:

A
  • Flood. Stoelting* ‘**s Pharmacology & Physiology in Anesthetic Practice. 5th ed. 2015. p. 85.
  • Hemmings. Pharmacology and Physiology for Anesthesia: Foundations and Clinical Application. 1st ed. 2013. p. 212-213, 219* & 393

Human basic neuroscience (68 decks)

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