Signal Transduction: From Receptor to Second Messenger Flashcards
Stimulation of which receptors increases phospholipase C? (Select 2.)
Study on!
In the last 2 questions, we examined the big picture and types of receptors. Now let’s connect each receptor to its effector and second messenger.
Let’s do it!!!
The alpha 1 receptor is associated with a —– protein for signal transduction
Gq
The alpha 2 receptor is associated with a —– protein for signal transduction
Gi
The beta 1 and beta 2 receptors are associated with a —– protein for signal transduction
Gs
The Nicotinic receptors in the ANS ganglia, NMJ & CNS are associated with —— for signal transduction
Ions channels
The Muscarinic 1/3/5 receptors are associated with a —– protein for signal transduction
Gq
The Muscarinic 2/4 receptors are associated with a —– protein for signal transduction
Gi
The Dopamine 1 (postsynaptic) receptor is associated with a —– protein for signal transduction
Gs
The Dopamine 2 (presynaptic) receptor is associated with a —– protein for signal transduction
Gi
The Vasopressin 1 (vasculature) receptor is associated with a —– protein for signal transduction
Gq
The Vasopressin 2 (renal tubules) receptor is associated with a —– protein for signal transduction
Gs
The Histamine 1 receptor is associated with a —– protein for signal transduction
Gq
The Histamine 2 receptor is associated with a —– protein for signal transduction
Gs
Activation of the Alpha 1 receptor (Gq) will turn on —–.
Phospholipase C
Activation of the Alpha 2 receptor (Gi) will turn off —–.
Adenylate cyclase
Activation of the beta 1 and beta 2 receptors (Gs) will turn on —–.
Adenylate cyclase
Activation of the Muscarinic 1/3/5 receptors (Gq) will turn ON —–.
Phospholipase C
Activation of the Muscarinic 2/4 receptors (Gi) will turn OFF —–.
Adenylate cyclase
Activation of the Dopamine 1 (postsynaptic) receptor (Gs) will turn ON —–.
Adenylate cyclase
Activation of the Dopamine 2 (presynaptic) receptor (Gi) will turn OFF —–.
Adenylate cyclase
Activation of the Vasopressin 1 (vasculature) receptor (Gq) will turn ON —–.
Phospholipase C
Activation of the Vasopressin 2 (renal tubules) receptor (Gs) will turn ON —–.
Adenylate cyclase
Activation of the Histamine 1 receptor (Gq) will turn ON —–.
Phospholipase C
Activation of the Histamine 2 receptor (Gq) will turn ON —–.
Adenylate cyclase
In general, activation of a receptor coupled to a Gq protein will turn ON —–.
Phospholipase C
In general, activation of a receptor coupled to a Gs protein will turn ON —–.
Adenylate cyclase
In general, activation of a receptor coupled to a Gi protein will turn OFF —–.
Adenylate cyclase
—–, —–, and —– are the 3 second messengers that are activated when Phospholipase C is turned ON
IP3, DAG, Ca+2
—– is the second messenger that is activated when Adenylate cyclase is turned ON
cAMP
—– is the second messenger that is deactivated when Adenylate cyclase is turned OFF
cAMP
IP3 =
Inositol trisphosphate
DAG =
Diacylglycerol
cAMP =
Cyclic adenosine monophosphate
Remember that the cellular response is —– specific
Tissue-specific
Which receptors are coupled to a Gq protein?
alpha 1
M1, 3, 5
V1
H1
Which receptors are coupled to a Gi protein?
alpha 2
M2, 4
D2
Which receptors are coupled to a Gs protein?
beta 1, 2
D1
V2
H2
Stimulation of which receptors increases phospholipase C? (Select 2.)
Alpha-1
Vasopressin-1
References:
- Flood. Stoelting* ‘**s Pharmacology & Physiology in Anesthetic Practice. 5th ed. 2015. p. 85.
- Hemmings. Pharmacology and Physiology for Anesthesia: Foundations and Clinical Application. 1st ed. 2013. p. 212-213, 219* & 393
