Cathecholamine Metabolism Flashcards
What is the end product of norepinephrine metabolism?
Oh boy!
What are the 2 metabolic pathways for norepinephrine and epinephrine?
- Monoamine oxidase (MAO)
- Catechol-O-methyltransferase (COMT)
The —– and the —– are the principal sites of metabolism of catecholamines that have entered the circulation
(this includes I V administration)
kidneys and liver
Only —–% of norepinephrine is excreted unchanged in the urine
~ 5%
The final byproduct of norepinephrine and epinephrine metabolism is —–.
Vanillyl-Mandelic Acid (VMA).
The final byproduct of norepinephrine and epinephrine metabolism is vanillylmandelic acid (VMA). Another name for this compound is —–.
3- methoxy-4-hydroxymandelic acid
—– measurement of VMA permits a general assessment of overall SNS activity
Urine measurement
The vast majority of VMA in the urine is the result of —– of norepinephrine
De-amination of norepinephrine
The vast majority of VMA in the urine is the result of de-amination of norepinephrine in —– nerve endings
Adrenergic post-ganglionic nerve endings
An elevated level of VMA in the urine aids in the diagnosis of —–.
Pheochromocytoma
What is the end product of norepinephrine metabolism?
Vanillylmandelic acid
Name 2 are Intermediate Metabolites of norepinephrine
metanephrine and normetanephrine
Name the precursor of NE synthesis.
Tyrosine
References:
- Barash. Clinical Anesthesia. 8th ed**.* 2017.* *p. 341-342.
- Flood* . Stoelting’s Pharmacalogy & Physiology in Anesthetic Practice . 5th ed. 2015. p**. 83 .