Shock

Question 1

Alpha-Adrenergic Activation

Answer 1

Upon circulatory failure, causes venular constriction which increases filtration out of capillaries, exacerbating shock

Question 2

2 Pathogenic Mechs of Arteriovenous Shunting & Which Shock Observed

Answer 2

Sludging of blood in caps cause it to go through metarterioles
Loss of arteriolar/venous resistance which makes capillary bed ineffective filter
Seen in septic shock

Question 3

4 Classifications of Shock

Answer 3

Hypovolemic
Cardiogenic
Obstructive
Distributive

Question 4

Distributive Shock

Answer 4

Changes in vascular resistance or capillary permeability, like sepsis, anaphylaxis, neurogenic, etc.

Question 5

Systemic Inflammatory Response Syndrome (pop at risk and 4 effects)

Answer 5

Common in IS pts, w/ sepsis release shit like LPS and stimulate TNF and IL1. These lead to vasodilation/decreased PVR, so increase in CO and low BP. Also Myocardial depression so decrease EF. Also increase NO production. Also complement cause increase permeability and cause leakage to EC space (warm shock, extremities warm despite low BP)

Question 6

Heart Complication from Shock

Answer 6

Decrease coronary flow, thus increasing myocardial dysfunction

Question 7

Adult Respiratory Distress Syndrome

Answer 7

Pulmonary capillary dysfunction from shock leading to edema and acute respiratory failure

Question 8

Hypovolemic Shock (RA, PCW (like LAFP), CO, SVR)

Answer 8

Low, Low, Low, High

Question 9

Cardiogenic Shock (RA, PCW (like LAFP), CO, SVR)

Answer 9

Variable, High, Low, High

Question 10

Septic Shock (RA, PCW (like LAFP), CO, SVR)

Answer 10

Low, Low, High (symp stimulation), Low

Question 11

Sepsis + Hydration (RA, PCW (like LAFP), CO, SVR)

Answer 11

Normal, Normal, High, Low

Question 12

Big Teller of Septic Shock

Answer 12

Warm skin w/ low BP