Changes at Birth

Question 1

Umbilical Cord 4 Contents

Answer 1

2 Umbilical A.s (deox)
1 Umbilical V.
Wharton’s Jelly (love lubing up with that shit knowhatimsayin?)

Question 2

Ductus Venosus

Answer 2

Carries high oxygenated blood from umbilical vein to IVC. Kinda like gate for fetal circulation

Question 3

Foramen Ovale

Answer 3

RA -> LA, bypass lungs so high O2 shit gets to brain and doesn’t overload lungs

Question 4

Ductus Arteriosus

Answer 4

Pulmonary a. -> aorta to protect lungs from circulatory overload

Question 5

Ibuprofen

Answer 5

Can close DA

Question 6

2 Important Things At Birth

Answer 6

Clamping Umbilical Cord - decrease umbilical flow, which constricts ductus venosus, decreases RAP, and resistance vessels chance to arterioles with much higher resistance so increase in SVR
First Cry/Breath - air expands lungs, decreasing PVR, decrease DA shunt, increase flow to lungs and return from lungs, so increase in LAP
Decrease in RAP and increase in LAP causes FO to close

Question 7

3 Biochemical Changes at Birth

Answer 7

Increase in O2
Decrease in PGs
Increase in bradykinins

Question 8

Oxygen in Newborn

Answer 8

Oxygen increases, which relaxes pulmonary smooth muscle and constricts DA and DV

Question 9

Fetal Myocardium

Answer 9

Fewer sarcomeres and less efficient contractile function (variety of factors), so has to adjust chronotropically. Neonate is kinda in the middle

Question 10

Persistent Pulmonary HTN of the Newborn (PPHN)

Answer 10

Persistent fetal circulation