Sex Cord Stromal Tumors

Question 1

Sertoli cell tumor histo

Answer 1

most are large cell calcifying, with tubule formation, abundant eosinophilic cytoplasm, myxoid or fibrotic storm, and prominent calcification
others demonstrate multiple cell types, which can be round with scant cytoplasm, fusiform, or large with abundant cytoplasm
others have small tubules of small cells with scant cytoplasm and dense fibrous stroma
no cytoplasmic crystals are present

Question 2

sertoli cell tumor assoc

Answer 2

Peutz-Jeghers syndrome

Question 3

leydig cell tumor histo

Answer 3

sheets and nests of monomorphic cells, round nuclei, and prominent nucleoli with abundant eosinophilic cytoplasm are seen
eosinophilic crystals may be present in the cytoplasm (Reinke crystals)

Question 4

granuloma cell tumor histo

Answer 4

adult: cells w elongated, grooved nuclei and scant cytoplasm form sheets called Call-Exner bodies (micro follicular sheets)
juvenile: cells with elongated but unproved nuclei and moderate amounts of cytoplasm form sheets and nests