Germ Cell Tumors

Question 1

yolk sac tumor histo

Answer 1

multiple histo patterns
may be microcytic, papillary, reticular, glandular, solid or hepatoid
schiller-duval bodies present in 50%

Question 2

yolk sac tumor AFP

Answer 2

elevated (>100)

Question 3

yolk sac tumor ß-hCG

Answer 3

negative

Question 4

choriocarcinoma histo

Answer 4

abundant necrosis and hemorrhage, mixed cytotrophoblasts and syncitiotrophoblasts

Question 5

choriocarcinoma AFP

Answer 5

negative

Question 6

choriocarcinoma ß-hCG

Answer 6

elevated (often >1000)

Question 7

teratoma histo

Answer 7

mature and immature components

mature: skin with adnexa, respiratory tract epithelium, GI epithelium, glial tissue
immature: undifferentiated, often primitive neuroepithelium

Question 8

teratoma AFP

Answer 8

negative

Question 9

teratoma ß-hCG

Answer 9

negative

Question 10

seminoma histo

Answer 10

classic seminoma: clonal cells with well-defined cytoplasmic borders; central nuclei with prominent nucleoli; and clear, glycogenated cytoplasm

Question 11

seminoma AFP

Answer 11

negative

Question 12

seminoma ß-hCG

Answer 12

may be mildly elevated

Question 13

embryonal histo

Answer 13

rarely present in pure form; demonstrates clusters and sheets of markedly atypical cells
may contain syncitiotrophoblast cells

Question 14

embryonal AFP

Answer 14

may have mild elevation, <60

Question 15

embryonal ß-hCG

Answer 15

may be mildly elevated