Seronegative spondyloarthropaties

Question 1

what are the five seronegative sponduloarthropathies

Answer 1

Reactive arthritis (ReA), ankylosing spondylitis (AS), psoriatic arthritis (PsA), spondylitis w/ IBD, undifferentiated

Question 2

genetic basis of seroneg spndyloarthropathies

Answer 2

HLS-B27: molecular mimicry with bacteria

Question 3

equation for developing ReA

Answer 3

genetic predisposition + exposure to germs

Question 4

features of seroneg spondyloarth

Answer 4

HLA-B27, enthesopathy, sacroiliitis, conjuctivitis, uveitis, mucocutaneous dz, arthritis, no RF

Question 5

structures involved in and features of anterior uveitis

Answer 5

iris, ciliary body, choroid; irregular pupis, hupopyon (settling of WBCs), photophobia

Question 6

keratoderma blennorrhagicum

Answer 6

crusts on skin (esp of hands and feet)

Question 7

what do we see in joint of inflamm arthritis

Answer 7

TNF-alpha. inject infiximab

Question 8

ReA: when? saying? joints? mechanism?

Answer 8

following GI or GU infection. “cant see cant pee cant climb a tree”. Additive of large joints. Molecular mimicry

Question 9

what is the synovial fluid like in ReA

Answer 9

inflammatory (high WBC) but sterile

Question 10

PsA: characteristics, joints?

Answer 10

nail pits, onycholysis, DIP involvement. Pencil in cup erosions

Question 11

AS: presentation, signs

Answer 11

young male, back pain improves w/ exercise. Dagger sign (ossification of ligaments), bamboo spine (syndesmophytes)

Question 12

IBD related arthritis: characteristics

Answer 12

non-erosive

Question 13

distinguish RA from ReA

Answer 13

DRB1 vs B27, enthesopathy, sacroiliitis, RF